Goserelin acetate
- CAS No.
- 145781-92-6
- Chemical Name:
- Goserelin acetate
- Synonyms
- Fertilan;Goserelin HCl;Goserelin acetate;Gosorelin Acetate;Goserelin Acteate;Goserilyn acetate;ICI-118630 acetate;Goserelin acetate/Fertilan;Goserelin?Acetate impurity;Goserelin Acetate(acetate)
- CBNumber:
- CB1281026
- Molecular Formula:
- C61H88N18O16
- Molecular Weight:
- 1329.49
- MDL Number:
- MFCD00867894
- MOL File:
- 145781-92-6.mol
- MSDS File:
- SDS
| Melting point | >190°C (dec.) |
|---|---|
| storage temp. | -20°C |
| solubility | H2O: 20 mg/mL, clear, colorless |
| form | white powder |
| color | White to Off-White |
| Stability | Hygroscopic |
| InChIKey | IKDXDQDKCZPQSZ-JHYYTBFNSA-N |
| NCI Dictionary of Cancer Terms | goserelin acetate |
| FDA UNII | 6YUU2PV0U8 |
| NCI Drug Dictionary | goserelin acetate |
| Proposition 65 List | Goserelin Acetate |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H360 | |||||||||
| Precautionary statements | P201-P202-P280-P308+P313-P405-P501 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | OK6369800 | |||||||||
| HS Code | 2937190000 | |||||||||
| NFPA 704 |
|
Goserelin acetate price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G4919 | Goserelin acetate ≥99% (HPLC), white powder | 145781-92-6 | 5mg | $110.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1297205 | Goserelin acetate United States Pharmacopeia (USP) Reference Standard | 145781-92-6 | 100mg | $1450 | 2024-03-01 | Buy |
| Cayman Chemical | 24071 | Goserelin (acetate) ≥98% | 145781-92-6 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 24071 | Goserelin (acetate) ≥98% | 145781-92-6 | 5mg | $116 | 2024-03-01 | Buy |
| Sigma-Aldrich | Y0001473 | Goserelin for NMR identification European Pharmacopoeia (EP) Reference Standard | 145781-92-6 | y0001473 | $223 | 2024-03-01 | Buy |
Goserelin acetate Chemical Properties,Uses,Production
Description
Goserelin acetate, like leuprolide acetate, is a synthetic superagonist nonapeptide analogue of
GnRH that possesses greater potency than the natural hormone. Note that it contains D-Ser(But)
and NH-NHCONH2 in place of Gly6 and Gly10-NH2, respectively. That is, the C terminal modification simply has an NH substituting for the CH2 of Gly, and like the C-terminal
change in leuprolide acetate, this inhibits enzymatic degradation of the peptide by the
postproline carboxyamide peptidase.
Goserelin acetate is available in the form of a small, solid pellet that is administered as an SC
implant for the palliative treatment of advanced, metastatic breast cancer in pre- and
perimenopausal women or, similarly, as a palliative in advanced prostatic cancer. The rationale
for this drug's use is, as described above, its ability as a superagonist to bring the levels of
estradiol or testosterone to near castrate levels, thus slowing the progression of breast or
prostate carcinoma, respectively. Additionally, goserelin acetate is approved for use in treating
endometriosis for up to 6 months.
Description
Goserelin is a synthetic gonadotropin-releasing hormone (GNRH) agonist that binds to the GNRH receptor (GNRHR; Ki = 1.6 nM, in CHO cells expressing the human receptor). It binds to mouse pituitary αT3-1 cells and human placenta (Kds = 2 and 580 nM, respectively) and increases intracellular calcium in αT3-1 cells. Goserelin induces testosterone production in vitro within 4 h in rat Leydig cells (ED50 = 83 nM) but decreases testosterone plasma level in vivo in rats over a period of 2 to 24 weeks. It inhibits tumor growth in a DU145 human prostate carcinoma mouse xenograft model when administered at a dose of 100 μg per day. Formulations containing goserelin have been used in the treatment of hormone-dependent breast and prostate cancers, as well as endometriosis and uterine fibroids.
Chemical Properties
White Solid
Uses
Synthetic peptide agonist analog of LH-RH. Antineoplastic (hormonal).
Uses
injectable gonadotropin releasing hormone superagonist (GnRH agonist) or luteinizing hormone antiproliferative activity in breast, prostate and endometrial cancers
Uses
Anticancer
General Description
Goserelin acetate is a synthetic decapaptide, which is a potent analog of LHRH (luteinizing hormone releasing hormone).
Biochem/physiol Actions
Goserelin acetate peptide results in significant inhibition of gonadotropin release and suppresses steroidogenesis in ovaries and testis. Thus, it leads to a reduction of testosterone to castration levels and estrogen to postmenopausal levels. Therefore, this peptide is used for reducing testosterone levels in patients with locally advanced prostate cancer.
Clinical Use
Goserelin acetate also is used in combination with the antiandrogen flutamide for shrinking
prostate carcinoma before radiation therapy. This maximal androgen blockade combination is
used when the prostate carcinoma has been staged as locally confined to the prostate gland,
with one or both lobes as well as the seminal vesicles involved. The treatment should start 8
weeks before radiation treatment begins and be continued throughout the radiation therapy.
Furthermore, women who are to undergo hysterectomy for menorrhagia can benefit from
previous treatment with goserelin acetate, because it is able to induce endometrial thinning.
This thinning of the endometrium improves the operating environment by causing less
intrauterine bleeding, increased postoperative amenorrhea, and decreased dysmenorrhea
following surgery, which is why goserelin acetate is approved for inducing endometrial thinning
prior to a patient undergoing a hysterectomy for heavy menstrual bleeding.
Goserelin acetate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 992 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10248 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Beijing Yibai Biotechnology Co., Ltd | 0086-182-6772-3597 | sales04@yibaibiotech.com | CHINA | 419 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from Goserelin acetate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-05-10 | Goserelin acetate
145781-92-6
|
US $70.00-700.00 / kg | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd | |
 |
2024-05-08 | Goserelin acetate
145781-92-6
|
US $0.00 / kg | 2kg | 98% up by HPLC, EP | 20tons | Sinoway Industrial co., ltd. | |
 |
2024-03-16 | Goserelin acetate
145781-92-6
|
US $0.00 / KG | 100g | 98%+ | 100kg | WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD |
-
- Goserelin acetate
145781-92-6
- US $70.00-700.00 / kg
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
-
- Goserelin acetate
145781-92-6
- US $0.00 / kg
- 98% up by HPLC, EP
- Sinoway Industrial co., ltd.
-
- Goserelin acetate
145781-92-6
- US $0.00 / KG
- 98%+
- WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
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