MK2-IN-1 (hydrochloride)
- CAS No.
- 1314118-94-9
- Chemical Name:
- MK2-IN-1 (hydrochloride)
- Synonyms
- MK 25;MK2 Inhibitor IV;MK 25 (hydrochloride);MK2-IN-1 (hydrochloride);MK2 inhibitor 1 hydrochloride;5-(4-Chlorophenyl)-N-(4-(piperazin-1-yl)phenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamide hydrochloride;5-(4-Chlorophenyl)-N-(4-(piperazin-1-yl)phenyl)-N-(pyridin-2-ylmethyl)furan-2-carboxamide hydrochloride[MK2 Inhibitor Hydrochloride];inhibit,MAP kinase activated protein kinase 2,MAPK activated protein kinase 2,MAPKAPK2 (MK2),Inhibitor,MK2IN1 hydrochloride,MK2 IN 1 hydrochloride,MAPKAP kinase 2,MK-2-IN-1 hydrochloride,Mitogen-activated protein kinase activated protein kinase 2
- CBNumber:
- CB13041430
- Molecular Formula:
- C27H26Cl2N4O2
- Molecular Weight:
- 509.43
- MDL Number:
- MFCD29472226
- MOL File:
- 1314118-94-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
MK2-IN-1 (hydrochloride) price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 14399 | MK2 Inhibitor IV ≥95% | 1314118-94-9 | 5mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 14399 | MK2 Inhibitor IV ≥95% | 1314118-94-9 | 10mg | $152 | 2024-03-01 | Buy |
| Cayman Chemical | 14399 | MK2 Inhibitor IV ≥95% | 1314118-94-9 | 25mg | $356 | 2024-03-01 | Buy |
| AK Scientific | 1740DU | MK2-IN-1hydrochloride | 1314118-94-9 | 50mg | $417 | 2021-12-16 | Buy |
| ChemScene | CS-4584 | MK2-IN-1hydrochloride 99.19% | 1314118-94-9 | 50mg | $480 | 2021-12-16 | Buy |
MK2-IN-1 (hydrochloride) Chemical Properties,Uses,Production
Biological Activity
mk2 inhibitor iv is a highly selective and non-atp competitive mk2 inhibitor with ic50 value of 0.11 μm [1].map kinase-activated protein kinase 2 (mapkapk2 or mk2) is a member of the ser/thr protein kinase family and regulated through direct phosphorylation by p38 map kinase. activation of the p38/mk2 pathway involved in promoting pro-inflammatory cytokine production and related inflammatory diseases [1].mk2 inhibitor iv is a highly selective and non-atp competitive mk2 inhibitor. in a broad panel of 150 protein kinases, mk2 inhibitor iv only significantly inhibited ck1γ3 at greater than 50%. mk2 inhibitor iv also demonstrated no inhibition against a panel of cytochrome p450 (cyp) enzymes up to 30 μm. in the human thp1 acute monocytic leukemia cell line, mk2 inhibitor iv inhibited pro-inflammatory cytokine secretion. mk2 inhibitor iv also dose-dependently inhibited lps-stimulated tnfα and il6 secretion with ic50 values of 4.4 μm and 5.2 μm, respectively. in the sw1353 chondrosarcoma cell line and human primary chondrocyte cultures, mk2 inhibitor iv dose dependently inhibited il1β-stimulated matrixmetalloprotease (mmp)13 secretion with ic50 values of 5.7 μm and 2.2 μm, respectively.
References
[1]. huang x, shipps gw jr, cheng cc, et al. discovery and hit-to-lead optimization of non-atp competitive mk2 (mapkapk2) inhibitors. acs med chem lett. 2011 jun 24;2(8):632-7.
MK2-IN-1 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3868 | 58 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | 1014988033@qq.com | China | 4981 | 55 |