Naloxegol Oxalate
- CAS No.
- 1354744-91-4
- Chemical Name:
- Naloxegol Oxalate
- Synonyms
- NKTR-118;NKTR 118 oxalate;Naloxegol Oxalate;AZ 13337019 oxalate;Naloxegol oxalate salt;NKTR-118;NKTR118;NKTR 118;Naloxegol Oxalate NKTR-118;(5alpha,6alpha)-4,5-Epoxy-6-(3,6,9,12,15,18,21-heptaoxadocos-1-yloxy)-17-(2-propen-1-yl)-morphinan-3,14-diol ethanedioate;Morphinan-3,14-diol,4,5-epoxy-6-(3,6,9,12,15,18,21-heptaoxadocos-1-yloxy)-17-(2-propen-1-yl)-,(5α,6α)-,ethanedioate(1:1)(salt);Naloxegol OxalateQ: What is Naloxegol Oxalate Q: What is the CAS Number of Naloxegol Oxalate Q: What is the storage condition of Naloxegol Oxalate
- CBNumber:
- CB13049698
- Molecular Formula:
- C36H55NO15
- Molecular Weight:
- 741.83
- MDL Number:
- MFCD29472292
- MOL File:
- 1354744-91-4.mol
- MSDS File:
- SDS
| Melting point | 92-95°C |
|---|---|
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| FDA UNII | 65I14TNM33 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS08,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H318-H334-H317-H341-H361-H370-H335-H413 | |||||||||
| Precautionary statements | P201-P202-P260-P264-P270-P272-P273-P280-P284-P302+P352-P304+P341-P305+P351+P338-P310-P308+P313-P321-P362+P364-P333+P313-P342+P311-P363-P405-P501 | |||||||||
| NFPA 704 |
|
Naloxegol Oxalate price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23731 | Naloxegol (oxalate) ≥98% | 1354744-91-4 | 5mg | $178 | 2024-03-01 | Buy |
| Cayman Chemical | 23731 | Naloxegol (oxalate) ≥98% | 1354744-91-4 | 10mg | $319 | 2024-03-01 | Buy |
| Cayman Chemical | 23731 | Naloxegol (oxalate) ≥98% | 1354744-91-4 | 25mg | $573 | 2024-03-01 | Buy |
| Cayman Chemical | 23731 | Naloxegol (oxalate) ≥98% | 1354744-91-4 | 50mg | $935 | 2024-03-01 | Buy |
| TRC | N284475 | NaloxegolOxalate | 1354744-91-4 | 25mg | $475 | 2021-12-16 | Buy |
Naloxegol Oxalate Chemical Properties,Uses,Production
Description
Naloxegol oxalate (XXI) is a peripherally acting μ-opioid receptor antagonist that was approved in the USA and EU for the treatment of opioid-induced constipation in adults with chronic non-cancer pain. The drug, a pegylated version of naloxone, has significantly reduced central nervous system (CNS) penetration and works by inhibiting the binding of opioids in the gastrointestinal tract. Naloxegol oxalate was developed by Nektar and licensed to AstraZeneca. Although we were unable to find a single report in the primary or patent literature that describes the exact experimental procedures to prepare naloxegol oxalate, there have been reports on the preparation of closely related analogs with specific reports on improving the selectivity of the reduction step156 and the salt formation of the final drug substance.
Uses
Naloxegol Oxalate is an oxalate form of Naloxegol (N284470) which is a peripherally-selective opioid antagonist.
Synthesis
Naloxone (180) was treated with methoxyethyl chloride in the presence of Hunig?ˉs base to give the protected ketone 181. Reduction of the ketone with potassium trisec- butylborohydride exclusively provided the a-alcohol 182 in 85% yield. Alternatively, sodium trialkylborohydrides could also be used to provide similar a-selective reduction in high yield. Deprotonation of the alcohol with sodium hydride followed by alkylation with CH3(OCH2CH2)7Br (183) provided the pegylated intermediate 184 in 88% yield. Acidic removal of the methoxyethyl ether protecting group followed by treatment with oxalic acid and crystallization provided naloxegol oxalate (XXI) in good yield.
Naloxegol Oxalate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12459 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503259 +86-19930503259 | cherry@crovellbio.com | China | 18452 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
View Lastest Price from Naloxegol Oxalate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-09-27 | Naloxegol Oxalate
1354744-91-4
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-09-06 | Naloxegol Oxalate
1354744-91-4
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Guanlang Biotechnology Co., Ltd. |
-
- Naloxegol Oxalate
1354744-91-4
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Naloxegol Oxalate
1354744-91-4
- US $0.00-0.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.