GPR39-C3
- CAS No.
- 1621175-65-2
- Chemical Name:
- GPR39-C3
- Synonyms
- CS-2374;GPR39-C3;TC-G-1008;GPR39C3;GPR39 C3;TC-G-1008 (GPR39-C3);inhibit,GHSR,Inhibitor,Growth hormone secretagogue receptor,TC G 1008,TCG1008;N-[3-Chloro-4-[[[2-(methylamino)-6-(2-pyridinyl)-4-pyrimidinyl]amino]methyl]phenyl]methanesulfonamide;N-(3-Chloro-4-(((2-(methylamino)-6-(pyridin-2-yl)pyrimidin-4-yl)amino)methyl)phenyl)methanesulfonamide;Methanesulfonamide, N-[3-chloro-4-[[[2-(methylamino)-6-(2-pyridinyl)-4-pyrimidinyl]amino]methyl]phenyl]-
- CBNumber:
- CB13126726
- Molecular Formula:
- C18H19ClN6O2S
- Molecular Weight:
- 418.9
- MDL Number:
- MFCD30182283
- MOL File:
- 1621175-65-2.mol
| Boiling point | 662.1±65.0 °C(Predicted) |
|---|---|
| Density | 1.462±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility |
DMSO:63.97(Max Conc. mg/mL);152.72(Max Conc. mM) DMSO:PBS (pH 7.2) (1:5):0.16(Max Conc. mg/mL);0.38(Max Conc. mM) Ethanol:2.0(Max Conc. mg/mL);4.77(Max Conc. mM) |
| form | A crystalline solid |
| pka | 7.43±0.10(Predicted) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
GPR39-C3 price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 25445 | GPR39-C3 ≥95% | 1621175-65-2 | 1mg | $33 | 2024-03-01 | Buy |
| Cayman Chemical | 25445 | GPR39-C3 ≥95% | 1621175-65-2 | 5mg | $137 | 2024-03-01 | Buy |
| Cayman Chemical | 25445 | GPR39-C3 ≥95% | 1621175-65-2 | 10mg | $238 | 2024-03-01 | Buy |
| Cayman Chemical | 25445 | GPR39-C3 ≥95% | 1621175-65-2 | 25mg | $515 | 2024-03-01 | Buy |
| Tocris | 5355 | TC-G1008 ≥98%(HPLC) | 1621175-65-2 | 10 | $227 | 2021-12-16 | Buy |
GPR39-C3 Chemical Properties,Uses,Production
Description
GPR39-C3 is a potent agonist of the orphan G protein-coupled receptor GPR39 with EC50 values of 0.8 and 0.4 nM for cAMP production in HEK293 cells expressing human and rat receptors, respectively. It is selective for GPR39 over a panel of kinases (IC50s = >10 μM), ghrelin and neurotensin-1 receptors (IC50s = >30 μM), and a variety of enzymes, transporters, or G protein-coupled receptors. GPR39-C3 increases secretion of glucagon-like peptide 1 (GLP-1; ) in STC-1 mouse enteroendocrine cells (EC50 = 0.06 μM) and is protective against cytokine-induced cell death in INS-1E rat insulinoma cells (EC50 = 0.02 μM). In vivo, GPR39-C3 (30 mg/kg) increases the amount of active GLP-1 in sera by 6-fold in glucose-challenged mice when administered concurrently with a dipeptidyl peptidase 4 (DPP-4) inhibitor.
Uses
TC-G 1008 is the first potent, selective, and orally bioavailable GPR39 agonist.
storage
Store at +4°C
GPR39-C3 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4604 | 58 |