FIIN-3
- CAS No.
- 1637735-84-2
- Chemical Name:
- FIIN-3
- Synonyms
- FIN-3;FIIN-3;CS-2331;FIIN3; FIIN 3;FIIN3; FIIN 3; FIIN-3;Inhibitor,FIIN 3,FIIN-3,HER1,FIIN3,ErbB-1,Epidermal growth factor receptor,inhibit,Fibroblast growth factor receptor,EGFR,FGFR;2-Propenamide, N-[4-[[[[(2,6-dichloro-3,5-dimethoxyphenyl)amino]carbonyl][6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]amino]methyl]phenyl]-
- CBNumber:
- CB13133445
- Molecular Formula:
- C34H36Cl2N8O4
- Molecular Weight:
- 691.61
- MDL Number:
- MFCD28386554
- MOL File:
- 1637735-84-2.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
FIIN-3 price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20709 | FIIN-3 ≥98% | 1637735-84-2 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 20709 | FIIN-3 ≥98% | 1637735-84-2 | 5mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 20709 | FIIN-3 ≥98% | 1637735-84-2 | 10mg | $283 | 2024-03-01 | Buy |
| Cayman Chemical | 20709 | FIIN-3 ≥98% | 1637735-84-2 | 25mg | $618 | 2024-03-01 | Buy |
| TRC | F336510 | FIIN-3 | 1637735-84-2 | 1mg | $145 | 2021-12-16 | Buy |
FIIN-3 Chemical Properties,Uses,Production
Description
FIIN-3 is an inhibitor of FGF receptors (FGFRs; IC50s = 13, 21, 31, and 35 nM for recombinant FGFR1-4, respectively). It is selective for FGFRs over a panel of 456 kinases at a concentration of 1 μM, however, it does inhibit EGFR (IC50 = 204 nM). FIIN-3 inhibits growth of Ba/F3 cells that are dependent on the kinase activity of wild-type FGFR1-4 as well as gatekeeper mutant FGFR2 and FGFR3 (EC50s = <1-69 nM) and inhibits FGFR-dependent signaling in a concentration-dependent manner in FGFR2TEL/V564M-dependent Ba/F3 cells. FIIN-3 also inhibits growth in a panel of cancer cell lines (EC50s = 1.4-499 nM).
Uses
FIIN-?3 is FGFR inhibitor. It can be used in synthetic preparation and complex with EGFR kinase of crystal structure; development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.
Definition
ChEBI: N-[4-[[[(2,6-dichloro-3,5-dimethoxyanilino)-oxomethyl]-[6-[4-(4-methyl-1-piperazinyl)anilino]-4-pyrimidinyl]amino]methyl]phenyl]-2-propenamide is a member of piperazines.
FIIN-3 Preparation Products And Raw materials
Raw materials
Preparation Products
FIIN-3 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| HangZhou YuHao Chemical Technology Co., Ltd. | 0571-82693216 | info@yuhaochemical.com | China | 2031 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4153 | 55 |