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Pamiparib

Pamiparib Structure
Pamiparib structure
CAS No.
1446261-44-4
Chemical Name:
Pamiparib
Synonyms
Pamiparib;bgb-290;EOS-61090;Pamiparib(BGB290);BGB-290,Pamiparib;Alflutinib Impurity 17;PAMIPARIB; BGB-290; BGB 290; BGB290.;inhibit,Pamiparib,PARP,Inhibitor,poly ADP ribose polymerase,BGB 290,BGB290;(R)-2-fluoro-10a-methyl-5,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one;(R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one
CBNumber:
CB13137483
Molecular Formula:
C16H15FN4O
Molecular Weight:
298.31
MDL Number:
MFCD30489383
MOL File:
1446261-44-4.mol
Last updated:2023-06-08 09:03:02
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Pamiparib Properties

Density 1.68±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF:20.0(Max Conc. mg/mL);67.04(Max Conc. mM)
DMF:PBS (pH 7.2) (1:10):0.09(Max Conc. mg/mL);0.3(Max Conc. mM)
DMSO:40.83(Max Conc. mg/mL);136.88(Max Conc. mM)
Ethanol:45.0(Max Conc. mg/mL);150.84(Max Conc. mM)
form A solid
pka 11.56±0.40(Predicted)
FDA UNII 8375F9S90C
NCI Drug Dictionary pamiparib

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS05,GHS06,GHS02
Signal word  Danger
Hazard statements  H300+H310+H330-H314-H226
Precautionary statements  P501-P260-P270-P262-P240-P210-P233-P243-P241-P242-P271-P264-P280-P284-P370+P378-P361+P364-P303+P361+P353-P301+P330+P331-P301+P310+P330-P304+P340+P310-P305+P351+P338+P310-P403+P233-P403+P235-P405
NFPA 704
0
2 0

Pamiparib price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0027388 Pamiparib 99.97% 1446261-44-4 5mg $90 2021-12-16 Buy
ChemScene CS-0027388 Pamiparib 99.97% 1446261-44-4 10mg $150 2021-12-16 Buy
ChemScene CS-0027388 Pamiparib 99.97% 1446261-44-4 25mg $250 2021-12-16 Buy
ChemScene CS-0027388 Pamiparib 99.97% 1446261-44-4 50mg $450 2021-12-16 Buy
ChemScene CS-0027388 Pamiparib 99.97% 1446261-44-4 100mg $750 2021-12-16 Buy
Product number Packaging Price Buy
CS-0027388 5mg $90 Buy
CS-0027388 10mg $150 Buy
CS-0027388 25mg $250 Buy
CS-0027388 50mg $450 Buy
CS-0027388 100mg $750 Buy

Pamiparib Chemical Properties,Uses,Production

Description

Pamiparib (BGB-290) is an investigational small molecule inhibitor of PARP1 and PARP2. Pamiparib is being evaluated as a monotherapy in pivotal clinical trials in China in recurrent platinum-sensitive and BRCA1/2 mutated ovarian cancers.

Uses

Pamiparib, is a PARP inhibitor, which can be used as an anticancer agent.

in vivo

Oral administration of Pamiparib results in time-dependent and dose-dependent inhibition of PARylation in MDA-MB-436 (BRCA1 mutant) breast cancer xenograft, correlating well with the tumor drug concentrations. It has also demonstrated good combination activity with chemotherapeutics in patient biopsy derived SCLC models. Also Pamiparib has significant brain penetration in C57 mice. The drug exposure in brain vs. that in plasma was close to 20% after oral administration of BGB-290.

Pamiparib synthesis

344-25-2
1446261-44-4
Synthesis of Pamiparib from D-Proline

Pamiparib Preparation Products And Raw materials

Raw materials

(3S,7aR)-3-(trichloroMethyl)tetrahydropyrrolo[1,2-c]oxazol-1(3H)-one methyl 3-amino-2-bromo-5-fluorobenzoate (R)-methyl 9-fluoro-11b-methyl-6-oxo-2,3,5,6,11,11b-hexahydro-1H-indolizino[8,7-b]indole-7-carboxylate 2-Methyl-1-pyrroline D-Proline

Preparation Products

Pamiparib Suppliers

Global( 79)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Shenzhen Shengda Pharma Limited 		755-85269922 +8613424394241 sales@shengdapharm.com CHINA 310 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24738 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8474 58
Nanjing Bicbiotechnology Co., Ltd 		+86-2552131256 +86-18251840740 sales@bicbiotech.com China 6000 58
Supplier Advantage
BOC Sciences 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Shenzhen Shengda Pharma Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58
LEAP CHEM CO., LTD. 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
TargetMol Chemicals Inc. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Nanjing Bicbiotechnology Co., Ltd 		58
(R)-2-fluoro-10a-methyl-7,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(5H)-one (R)-2-fluoro-10a-methyl-5,8,9,10,10a,11-hexahydro-5,6,7a,11-tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one 5,6,7a,11-Tetraazacyclohepta[def]cyclopenta[a]fluoren-4(7H)-one, 2-fluoro-5,8,9,10,10a,11-hexahydro-10a-methyl-, (10aR)- PAMIPARIB; BGB-290; BGB 290; BGB290. BGB-290,Pamiparib Pamiparib(BGB290) EOS-61090 bgb-290 Pamiparib inhibit,Pamiparib,PARP,Inhibitor,poly ADP ribose polymerase,BGB 290,BGB290 (2R)-14-fluoro-2-methyl-6,9,10,19-tetraazapentacyclo[14.2.1.02,?.0?,1?.012,1?]nonadeca-1(18),8,12(17),13,15-pentaen-11-one Alflutinib Impurity 17 1446261-44-4 1446261-44-1 APIS