IOX4
- CAS No.
- 1154097-71-8
- Chemical Name:
- IOX4
- Synonyms
- IOX4;IOX4 NEW;IOX4; IOX-4; IOX 4;PHD2 inhibitor IOX4;t-butyl 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate;tert-butyl 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate;IOX 4,HIF-PH,HIFs,Hypoxia-inducible factors,IOX4,IOX-4,inhibit,HIF/HIF Prolyl-Hydroxylase,Inhibitor;3-Pyridinecarboxylic acid, 6-[2,5-dihydro-5-oxo-4-(1H-1,2,3-triazol-1-yl)-1H-pyrazol-1-yl]-, 1,1-dimethylethyl ester
- CBNumber:
- CB13152631
- Molecular Formula:
- C15H16N6O3
- Molecular Weight:
- 328.33
- MDL Number:
- MFCD31691406
- MOL File:
- 1154097-71-8.mol
| Melting point | >190° (dec.) |
|---|---|
| Boiling point | 502.2±60.0 °C(Predicted) |
| Density | 1.41±0.1 g/cm3(Predicted) |
| storage temp. | Refrigerator, Under inert atmosphere |
| solubility | DMSO (Sparingly, Sonicated), Methanol (Slightly, Sonicated) |
| form | Solid |
| pka | 1.36±0.29(Predicted) |
| color | Light Beige to Beige |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
IOX4 price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18181 | IOX4 ≥98% | 1154097-71-8 | 5mg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 18181 | IOX4 ≥98% | 1154097-71-8 | 10mg | $138 | 2024-03-01 | Buy |
| Cayman Chemical | 18181 | IOX4 ≥98% | 1154097-71-8 | 25mg | $324 | 2024-03-01 | Buy |
| Cayman Chemical | 18181 | IOX4 ≥98% | 1154097-71-8 | 50mg | $575 | 2024-03-01 | Buy |
| TRC | I737010 | IOX4 | 1154097-71-8 | 250mg | $1440 | 2021-12-16 | Buy |
IOX4 Chemical Properties,Uses,Production
Description
IOX4 is a potent inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 (HIF-PH2; IC50 = 1.6 nM). It displays >1,000-fold selectivity for PHD2 over other 2OG-dependent dioxygenases, including JMJD isoforms, FBXL11, JARID1C, BBOX1, FIH, and FTO. IOX4 is active in vivo, inhibiting prolyl hydroxylation and increasing HIF-1α levels in cells (IC50 values range from 5.6 to 11.7 μM) and inducing HIF-1α and HIF-2α expression in mice. The induction of HIF expression in mice occurs in the brain as well as in the liver, kidney, and heart, indicating that IOX4 penetrates the blood-brain barrier.
Uses
IOX4 is a triazole based potent and selective inhibitor of hypoxia-inducible factor (HIF) prolyl-hydroxylase. It induces HIFα in cells of mouse brain. It is useful for studies that aim to validate the upregulation of HIF for treatment of cerebral diseases such as stroke.
IOX4 Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| HangZhou YuHao Chemical Technology Co., Ltd. | 0571-82693216 | info@yuhaochemical.com | China | 2031 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4153 | 55 |