Tucidinostat (Chidamide)
- CAS No.
- 1616493-44-7
- Chemical Name:
- Tucidinostat (Chidamide)
- Synonyms
- CS055;TUCIDINOSTAT;Cidabenzamine;CS055; HBI-8000;HBI-8000， CS-055;Chidamide (Tucidinostat, HBI8000, CS 055);Tucidinostat - Chidamide | HBI-8000 | CS 055 | Epidaza;HDAC,HBI8000,CS055,Tucidinostat,Histone deacetylases,CS-055,Inhibitor,HBI 8000,inhibit;N-(2-Amino-4-fluorophenyl)-4-[[[(2E)-1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]benzamide;Benzamide, N-(2-amino-4-fluorophenyl)-4-[[[(2E)-1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-
- CBNumber:
- CB13389703
- Molecular Formula:
- C22H19FN4O2
- Molecular Weight:
- 390.41
- MDL Number:
- MOL File:
- 1616493-44-7.mol
| Boiling point | 602.1±55.0 °C(Predicted) |
|---|---|
| Density | 1.336±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml |
| form | A crystalline solid |
| pka | 12.05±0.70(Predicted) |
| FDA UNII | 87CIC980Y0 |
| NCI Drug Dictionary | tucidinostat |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Tucidinostat (Chidamide) price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 13686 | Chidamide | 1616493-44-7 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 13686 | Chidamide | 1616493-44-7 | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 13686 | Chidamide | 1616493-44-7 | 10mg | $195 | 2024-03-01 | Buy |
| Cayman Chemical | 13686 | Chidamide | 1616493-44-7 | 25mg | $266 | 2024-03-01 | Buy |
| TRC | C291980 | Chidamide | 1616493-44-7 | 250mg | $1320 | 2021-12-16 | Buy |
Tucidinostat (Chidamide) Chemical Properties,Uses,Production
Description
Chidamide is an inhibitor of histone deacetylases (HDACs; IC50s = 0.095, 0.160, 0.067, 0.733, 0.078, and 0.432 μM for HDAC1-3, 8, 10, and 11, respectively). It is selective for these HDACs over HDAC4-7 and 9 (IC50s = >30 μM for all). Chidamide also inhibits nicotinamide phosphoribosyltransferase (Nampt; IC50 = 2.1 μM). It inhibits cell growth in a panel of 18 cancer cell lines (GI50s = 0.4-40 μM) but has no effect on the growth of non-cancerous CCC-HEK human fetal kidney or CCC-HEL human liver cells (GI50s = >100 μM). In vivo, tucidinostat (12.5, 25, and 50 mg/kg) reduces tumor growth in HCT-8, A549, BEL-7402, and MCF-7 mouse xenograft models.
Uses
Chidamide is a newly designed histone deacetylase inhibitor that induces an antitumor effect in various cancer by increasing the acetylation levels of histone H3 and decrease histone deacetylase (HDAC) activity, induces apoptosis. Also, it is a potential utility of Chidamide for the treatment of Myelodysplastic syndromes.
Definition
ChEBI: Chidamide is a member of benzamides.
Tucidinostat (Chidamide) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618829768577 | gao490372054@gamil.com | China | 1250 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
View Lastest Price from Tucidinostat (Chidamide) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-12 | Tucidinostat (Chidamide)
1616493-44-7
|
US $0.00 / kg | 1kg | 99% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd | |
 |
2019-07-06 | Tucidinostat (Chidamide)
1616493-44-7
|
US $1.00 / KG | 1KG | 98-100% | 1000kg | Career Henan Chemical Co |
-
- Tucidinostat (Chidamide)
1616493-44-7
- US $0.00 / kg
- 99%
- Shaanxi Haibo Biotechnology Co., Ltd
-
- Tucidinostat (Chidamide)
1616493-44-7
- US $1.00 / KG
- 98-100%
- Career Henan Chemical Co