1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine
- CAS No.
- 831234-13-0
- Chemical Name:
- 1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine
- Synonyms
- AC1903;AC1903 AC-1903;AC1903 >=98% (HPLC);1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine;1-benzyl-N-(furan-2-ylmethyl)-1H-benzo[d]imidazol-2-amine;1-Benzyl-N-[(furan-2-yl)methyl]-1H-1,3-benzodiazol-2-amine;1H-Benzimidazol-2-amine, N-(2-furanylmethyl)-1-(phenylmethyl)-;Inhibitor,glomerulosclerosis,proteinuria,inhibit,TRP Channel,ros,focal segmental,AC 1903,Transient receptor potential channels,AC-1903,FSGS,AC1903,kidney disease,podocyte loss,HEK-293
- CBNumber:
- CB14243558
- Molecular Formula:
- C19H17N3O
- Molecular Weight:
- 303.36
- MDL Number:
- MFCD06609959
- MOL File:
- 831234-13-0.mol
| Boiling point | 512.4±60.0 °C(Predicted) |
|---|---|
| Density | 1.20±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 25 mg/ml) |
| pka | 6.09±0.10(Predicted) |
| form | solid |
| color | Beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 25324 | AC1903 ≥95% | 831234-13-0 | 5mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 25324 | AC1903 ≥95% | 831234-13-0 | 10mg | $87 | 2024-03-01 | Buy |
| Tocris | 6766 | AC1903 ≥98%(HPLC) | 831234-13-0 | 25 | $275 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb546177 | AC1903 >98% | 831234-13-0 | 10mg | $190.4 | 2021-12-16 | Buy |
| ChemScene | CS-0081483 | AC1903 98.64% | 831234-13-0 | 25mg | $240 | 2021-12-16 | Buy |
1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine Chemical Properties,Uses,Production
Description
AC1903 is an inhibitor of transient receptor potential canonical channel 5 (TRPC5; IC50 = 14.7 μM). It is selective for TRPC5 over TRPC4 and TRPC6 at concentrations up to 100 and 30 μM, respectively. It inhibits TRPC5 in a concentration-dependent manner in HEK293 cells when used at concentrations ranging from 1 to 100 μM. AC1903 (30 μM) inhibits angiotensin II-induced production of reactive oxygen species (ROS) in wild-type podocytes and podocytes expressing a mutant angiotensin II type 1 (AT1) receptor that cannot be inactivated and endocytosed. It also suppresses proteinuria as well as reduces pseudocyst formation and podocyte loss in an AT1 receptor transgenic rat model of kidney disease when administered at a dose of 50 mg/kg twice per day. In a model of hypertension-induced focal segmental glomerulosclerosis (FSGS) using Dahl salt-sensitive rats, AC1903 decreases the rate of proteinuria when administered at the beginning of a high-salt diet and prevents progression when administered one week following initiation of a high-salt diet.
Uses
AC1903 is a TRPC5 inhibitor with valuable potential for the treatment of progressive kidney diseases. AC1903 inhibits TRPC5 ion channels and suppresses progressive kidney diseases via TRPC5-AT1R related genetic pathways. ?AC1903 also provides therapeutic benefit in a rat model of hypertensive proteinuric kidney disease.
storage
Store at -20°C
References
1) Zhou?et al.?(2017),?A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models; Science,?358?1332
1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine Preparation Products And Raw materials
Raw materials
Preparation Products
1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 15162312715 | sales@szzxbio.com | China | 2981 | 58 |
| Nantong MYBio-pharm. Co., Ltd. | 0513-66921823 18662920231 | sales@minyanmedical.com | China | 3069 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4153 | 55 | |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| ShangHai Angti Biotechnology Co., Ltd. | 13764913901 | info@angtibio.com | China | 4678 | 55 |