AM 92016 hydrochloride
- CAS No.
- 133229-11-5
- Chemical Name:
- AM 92016 hydrochloride
- Synonyms
- AM92016,Inhibitor,inhibit,AM 92016,AM 92016 hydrochloride,AM92016 hydrochloride,AM-92016;N-[4-[3-[[2-(3,4-Dichlorophenyl)ethyl]methylamino]-2-hydroxypropoxy]phenyl]methanesulfonamide hydrochloride
- CBNumber:
- CB14806425
- Molecular Formula:
- C19H25Cl3N2O4S
- Molecular Weight:
- 483.83
- MDL Number:
- MOL File:
- 133229-11-5.mol
AM 92016 hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A634675 | AM92016Hydrochloride | 133229-11-5 | 1mg | $105 | 2021-12-16 | Buy |
| ApexBio Technology | B6482 | AM92016hydrochloride | 133229-11-5 | 5mg | $158 | 2021-12-16 | Buy |
| ApexBio Technology | B6482 | AM92016hydrochloride | 133229-11-5 | 10mg | $284 | 2021-12-16 | Buy |
| ApexBio Technology | B6482 | AM92016hydrochloride | 133229-11-5 | 50mg | $929 | 2021-12-16 | Buy |
| DC Chemicals | DC26176 | AM92016 | 133229-11-5 | 100mg | $600 | 2021-12-16 | Buy |
AM 92016 hydrochloride Chemical Properties,Uses,Production
Biological Activity
am 92016 hydrochloride is a specific inhibitor of delayed rectifier potassium current [1].potassium channel is an ion channel and acts to reset the resting potential and shapes the action potential. delayed rectifier potassium channel (ik) is activated by the influx of na+ and discharges k+, which repolarizes the membrane. ik restricts the duration of the nerve impulse.am 92016 hydrochloride is a specific ik inhibitor. in guinea-pig and rabbit ventricular cells, am 92016 significantly increased action potential duration with 20% and 90% repolarization levels, respectively. also, am 92016 (1 μm) inhibited ik activated by step depolarizations in a time-dependent way [1]. in rabbit sino-atrial node cells, am 92016 (50 nm) significantly inhibited ik with ic50 value of 40 nm in a concentration-dependent way [2]. in vascular smooth muscle cells (vsmc), am92016 hydrochloride inhibited no-induced erk1/2 dephosphorylation [3].in guinea-pigs, am 92016 (1-5 mg/kg) significantly increased heart rate, left ventricular systolic pressure, systolic arterial blood pressure and the contractile index dp dtmax. am 92016 exhibited proarrhythmic activity [4].
References
[1]. connors sp, gill ew, terrar da. actions and mechanisms of action of novel analogues of sotalol on guinea-pig and rabbit ventricular cells. br j pharmacol, 1992, 106(4): 958-965.
[2]. lei m, brown hf. inhibition by compound ii, a sotalol analogue, of delayed rectifier current (ik) in rabbit isolated sino-atrial node cells. naunyn schmiedebergs arch pharmacol, 1998, 357(3): 260-267.
[3]. palen di, belmadani s, lucchesi pa, et al. role of shp-1, kv.1.2, and cgmp in nitric oxide-induced erk1/2 map kinase dephosphorylation in rat vascular smooth muscle cells. cardiovasc res, 2005, 68(2): 268-277.
[4]. hagerty mj, wainwright cl, kane ka. the in-vivo cardiovascular effects of a putative class iii anti-arrhythmic drug, am 92016. j pharm pharmacol, 1996, 48(4): 417-421.
AM 92016 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
AM 92016 hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 18112977050 | cb6@aikonchem.com | China | 16687 | 50 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2993 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9767 | 58 |