ChemicalBook >> CAS DataBase List >>Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester
Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester
![Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester Structure](CAS/20200331/GIF/1858276-04-6.gif)
- CAS No.
- 1858276-04-6
- Chemical Name:
- Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester
- Synonyms
- TAK-981;Subasumstat;Subasumstat(TAK-981);((1R,2S,4R)-4-((5-(4-((R)-7-Chloro-1,2,3,4-tetrahydroisoquinolin-1-yl)-5-methylthiophene-2-carbonyl)pyrimidin-4-yl)amino)-2-hydroxycyclopentyl)methyl sulfamate;(1R，2S，4R)-4-{[5-({4-[(1R)-7-chloro-1，2，3，4-tetrahydroisoquinolin-1-yl]-5-methyl-2-thienyl}carbonyl)pyrimidin-4-yl]amino}-2-hydroxycyclopentyl]methyl sulfamate;(1R,2S,4R)-4-[[5-[4-[(1R)-7-Chloro-1,2,3,4-tetrahydroisoquinolin-1-yl]-5-methylthiophene-2-carbonyl]pyrimidin-4-yl]amino]-2-hydroxycyclopentyl]methyl sulfamate;Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester;inhibit,Ubiquitin ligase,E1/E2/E3 Enzyme,Subasumstat,TAK 981,E1 activating enzyme,Ubiquitin conjugating enzyme,Inhibitor,E2 conjugating enzyme,TAK981,Ubiquitin activating enzyme,E3 ligating enzyme
- CBNumber:
- CB15488093
- Molecular Formula:
- C25H28ClN5O5S2
- Molecular Weight:
- 578.1
- MDL Number:
- MFCD32062692
- MOL File:
- 1858276-04-6.mol
Last updated:2023-05-21 10:59:17
Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester Properties
| Boiling point | 836.1±75.0 °C(Predicted) |
|---|---|
| Density | 1.474±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 16.67 mg/mL (28.84 mM; ultrasonic and warming and heat to 80°C) |
| form | A solid |
| pka | 9.35±0.70(Predicted) |
| FDA UNII | XQ43H3V6M1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C351340 | TAK-981 | 1858276-04-6 | 2.5mg | $1470 | 2021-12-16 | Buy |
| ChemScene | CS-0091878 | Subasumstat 98.56% | 1858276-04-6 | 100mg | $1650 | 2021-12-16 | Buy |
| ChemScene | CS-0091878 | Subasumstat 98.56% | 1858276-04-6 | 5mg | $200 | 2021-12-16 | Buy |
| ChemScene | CS-0091878 | Subasumstat 98.56% | 1858276-04-6 | 10mg | $310 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0009808 | TAK-981 95.00% | 1858276-04-6 | 5MG | $454.35 | 2021-12-16 | Buy |
Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester Chemical Properties,Uses,Production
Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester Suppliers
Global( 27)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4153 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Dezhou LonWel Pharmaceutical Technology Co., Ltd. | 13761310616 | 39324283@qq.com | China | 1971 | 58 |
| Shanghai Aocheng Biological Technology Co., Ltd. | 13917627064 | 56229367@qq.com | China | 564 | 58 |
| Taizhou Crene Biotechnology Co. Ltd. | 0576-88813233 13396860566 | sales@pharm-intermediates.com | China | 2013 | 58 |
Sulfamic acid, [(1R,2S,4R)-4-[[5-[[4-[(1R)-7-chloro-1,2,3,4-tetrahydro-1-isoquinolinyl]-5-methyl-2-thienyl]carbonyl]-4-pyrimidinyl]amino]-2-hydroxycyclopentyl]methyl ester
TAK-981
(1R,2S,4R)-4-[[5-[4-[(1R)-7-Chloro-1,2,3,4-tetrahydroisoquinolin-1-yl]-5-methylthiophene-2-carbonyl]pyrimidin-4-yl]amino]-2-hydroxycyclopentyl]methyl sulfamate
Subasumstat
((1R,2S,4R)-4-((5-(4-((R)-7-Chloro-1,2,3,4-tetrahydroisoquinolin-1-yl)-5-methylthiophene-2-carbonyl)pyrimidin-4-yl)amino)-2-hydroxycyclopentyl)methyl sulfamate
Subasumstat(TAK-981)
inhibit,Ubiquitin ligase,E1/E2/E3 Enzyme,Subasumstat,TAK 981,E1 activating enzyme,Ubiquitin conjugating enzyme,Inhibitor,E2 conjugating enzyme,TAK981,Ubiquitin activating enzyme,E3 ligating enzyme
(1R，2S，4R)-4-{[5-({4-[(1R)-7-chloro-1，2，3，4-tetrahydroisoquinolin-1-yl]-5-methyl-2-thienyl}carbonyl)pyrimidin-4-yl]amino}-2-hydroxycyclopentyl]methyl sulfamate
1858276-04-6
C25H28ClN5O5S2