PK150
- CAS No.
- 2165324-62-7
- Chemical Name:
- PK150
- Synonyms
- PK150;1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)urea;Urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(2,2-difluoro-1,3-benzodioxol-5-yl)-;Bacterial,MRSA,MSSA,Gram-positive,PK-150,antibacterial,PK 150,PK150,Inhibitor,VISA,inhibit
- CBNumber:
- CB15832810
- Molecular Formula:
- C15H8ClF5N2O3
- Molecular Weight:
- 394.68
- MDL Number:
- MFCD32667017
- MOL File:
- 2165324-62-7.mol
| Boiling point | 322.1±42.0 °C(Predicted) |
|---|---|
| Density | 1.63±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to at least 25 mg/ml). |
| pka | 12.44±0.40(Predicted) |
| form | solid |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
PK150 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SBR00043 | PK150 Sorafenib analog | 2165324-62-7 | 10MG | $99 | 2023-06-20 | Buy |
| Adipogen Life Sciences | AG-CR1-0162-M025 | PK150(SorafenibAnalog) ≥98%(HPLC) | 2165324-62-7 | 25mg | $120 | 2021-12-16 | Buy |
| ChemScene | CS-0112109 | PK150 99.37% | 2165324-62-7 | 5mg | $150 | 2021-12-16 | Buy |
| ChemScene | CS-0112109 | PK150 99.37% | 2165324-62-7 | 10mg | $250 | 2021-12-16 | Buy |
| ChemScene | CS-0112109 | PK150 99.37% | 2165324-62-7 | 50mg | $750 | 2021-12-16 | Buy |
PK150 Chemical Properties,Uses,Production
Description
PK150 (2165324-62-7) is a Sorafenib analog that displays significant antibacterial activity against several pathogenic strains (S.aureus?NCTC8325, MIC = 0.3 μM; vancomycin -resistant enterococci, MIC = 3 μM; and?M.tuberculosis?MIC = 2 μM). It was inactive against Gram-negative bacteria. It effectively reduced persister cells in ciprofloxacin-treated stationary?S.aureus?cultures and effectively eradicated staphylococcus biofilms. PK150 did not develop antibacterial resistance in an agar-plate-based assay. Its antibacterial properties were attributed to demethylmenaquinone methyltransferase (MenG) inhibition and signal peptidase IB (SpsB) activation. PK150 displayed?in vivo?efficacy in a murine bloodstream infection model against methicillin-sensitive?S. aureus?and a neutropenic mouse thigh model against methicillin-resistant?S. aureus?strain ATCC33591. Inactive against a panel of over 250 human kinases.
References
1) Le?et al.?(2019)?Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms; Nat. Chem.?12?145
PK150 Preparation Products And Raw materials
Raw materials
Preparation Products
PK150 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3501 | 55 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9414 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 3689 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 15221909166 | product02@bidepharm.com | China | 63720 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6713 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |