ChemicalBook >> CAS DataBase List >>Thalidomide-NH-CH2-COOH
Thalidomide-NH-CH2-COOH
- CAS No.
- 927670-97-1
- Chemical Name:
- Thalidomide-NH-CH2-COOH
- Synonyms
- Thalidomide-NH-CH2-COOH;6-dioxopiperidin-3-yl)-1;3-dioxoisoindolin-4-yl)glycine;3-dioxoisoindol-4-yl]amino]acetic acid;(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine;2-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]amino]acetic acid;Glycine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-;[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]acetic acid;inhibit,Ligands for E3 Ligase,E3 ligase-recruiting Moiety,Inhibitor,Thalidomide NH CH2 COOH,ThalidomideNHCH2COOH,cereblon,Thalidomide-NH-CH-2-COOH,CRBN,Thalidomide
- CBNumber:
- CB18197022
- Molecular Formula:
- C15H13N3O6
- Molecular Weight:
- 331.28
- MDL Number:
- MFCD31667076
- MOL File:
- 927670-97-1.mol
Last updated:2023-12-28 09:17:25
| Boiling point | 713.9±60.0 °C(Predicted) |
|---|---|
| Density | 1.637±0.06 g/cm3(Predicted) |
| solubility | DMSO : 50 mg/mL (150.93 mM; Need ultrasonic) |
| pka | 3.92±0.10(Predicted) |
| InChI | InChI=1S/C15H13N3O6/c19-10-5-4-9(13(22)17-10)18-14(23)7-2-1-3-8(12(7)15(18)24)16-6-11(20)21/h1-3,9,16H,4-6H2,(H,20,21)(H,17,19,22) |
| InChIKey | LRGLFYOYKPSPJQ-UHFFFAOYSA-N |
| SMILES | C(O)(=O)CNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O |
Thalidomide-NH-CH2-COOH Chemical Properties,Uses,Production
Definition
Thalidomide-NH-CH2-COOH contains a thalidomide group, an amide, an alkylC2 chain, and a terminal carboxylic acid. This product is ready for conjugation to target proteins for PROTAC R&D. It is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. This compound also can be connected to the ligand for protein by a linker to form PROTACs, such as THAL-SNS-032 (HY-123937).
Thalidomide-NH-CH2-COOH Preparation Products And Raw materials
Raw materials
Preparation Products
Thalidomide-NH-CH2-COOH Suppliers
Global( 27)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Zhengzhou Lingzhiyue Technology Co., Ltd | +86-0371-55074660 +86-13783527580 | Lingzhiyue@aliyun.com | China | 3144 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Suzhou Origin Specialty Chemicals Co., Ltd. | +86-512-68662322 +86-17312436797 | hanqun@origsc.com | China | 788 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323967 +86-18015559028 | sales1@artkmedchem.com | China | 39009 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9767 | 58 |
| Shanghai CR Corporation Limited | 4006653949 | fred.wen@crcorporation.cn | China | 10108 | 58 |
| Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 | 1927928688@qq.com | China | 1305 | 58 |
| Lingyuan Bebiansen Biological Technology Co., Ltd | 18642120371 | 2837458851@qq.com | China | 9874 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 400-8210725 4008210725 | malulu@leyan.com | China | 39997 | 58 |
Glycine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-
[(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl)amino]acetic acid
Thalidomide-NH-CH2-COOH
3-dioxoisoindol-4-yl]amino]acetic acid
3-dioxoisoindolin-4-yl)glycine
6-dioxopiperidin-3-yl)-1
(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine
inhibit,Ligands for E3 Ligase,E3 ligase-recruiting Moiety,Inhibitor,Thalidomide NH CH2 COOH,ThalidomideNHCH2COOH,cereblon,Thalidomide-NH-CH-2-COOH,CRBN,Thalidomide
2-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]amino]acetic acid
927670-97-1