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ChemicalBook >> CAS DataBase List >>4(3H)-Pyrimidinone, 6-methyl-2-[[2-(1-naphthalenyl)-2-oxoethyl]thio]-

4(3H)-Pyrimidinone, 6-methyl-2-[[2-(1-naphthalenyl)-2-oxoethyl]thio]-

4(3H)-Pyrimidinone, 6-methyl-2-[[2-(1-naphthalenyl)-2-oxoethyl]thio]- Structure
4(3H)-Pyrimidinone, 6-methyl-2-[[2-(1-naphthalenyl)-2-oxoethyl]thio]- structure
CAS No.
459420-09-8
Chemical Name:
4(3H)-Pyrimidinone, 6-methyl-2-[[2-(1-naphthalenyl)-2-oxoethyl]thio]-
Synonyms
HMPSNE;13MT-3;I3MT-3;6-Methyl-2-((2-(naphthalen-1-yl)-2-oxoethyl)thio)pyrimidin-4(3H)-one;4(3H)-Pyrimidinone, 6-methyl-2-[[2-(1-naphthalenyl)-2-oxoethyl]thio]-;6-Methyl-2-((2-(naphthalen-1-yl)-2-oxoethyl)thio)pyrimidin-4(3H)-one[I3MT-3;EA.hy926 cells,Hippo (MST),inhibit,I3MT-3,3MST,HEK293,I3MT3,cell-membrane,COS-7,I-3MT-3,I3MT 3,Inhibitor
CBNumber:
CB18233171
Molecular Formula:
C17H14N2O2S
Molecular Weight:
310.37
MDL Number:
MFCD33023210
MOL File:
459420-09-8.mol
Last updated:2023-05-21 10:59:17
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4(3H)-Pyrimidinone, 6-methyl-2-[[2-(1-naphthalenyl)-2-oxoethyl]thio]- Properties

Boiling point 514.9±52.0 °C(Predicted)
Density 1.30±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 125 mg/mL (402.75 mM)
pka 7.72±0.50(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

4(3H)-Pyrimidinone, 6-methyl-2-[[2-(1-naphthalenyl)-2-oxoethyl]thio]- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0095460 I3MT-3 99.90% 459420-09-8 10mg $450 2021-12-16 Buy
ChemScene CS-0095460 I3MT-3 99.90% 459420-09-8 25mg $850 2021-12-16 Buy
ChemScene CS-0095460 I3MT-3 99.90% 459420-09-8 100mg $1950 2021-12-16 Buy
Product number Packaging Price Buy
CS-0095460 10mg $450 Buy
CS-0095460 25mg $850 Buy
CS-0095460 100mg $1950 Buy

4(3H)-Pyrimidinone, 6-methyl-2-[[2-(1-naphthalenyl)-2-oxoethyl]thio]- Chemical Properties,Uses,Production

Biological Activity

I3MT-3 (HMPSNE) is a potent, selective and cell membrane permeable inhibitor of 3-mercaptopyruvate sulfurtransferase (3MST) (IC50=2.7 μM), inactive against other hydrogen sulfide/sulfanilamide sulfur enzymes. I3MT-3 targets a perthiocysteine residue located in the active site of 3MST.

target

IC50: 2.7 μM (3-Mercaptopyruvate sulfurtransferase (3MST))

4(3H)-Pyrimidinone, 6-methyl-2-[[2-(1-naphthalenyl)-2-oxoethyl]thio]- Preparation Products And Raw materials

Raw materials

Preparation Products

4(3H)-Pyrimidinone, 6-methyl-2-[[2-(1-naphthalenyl)-2-oxoethyl]thio]- Suppliers

Global( 21)Suppliers
Supplier Tel Email Country ProdList Advantage
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 3501 55
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 8011 62
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 9754 58
MQ (shanghai) Pharmaceuticals Co., Ltd. 13761635123 1014988033@qq.com China 4981 55
Zhengzhou Huiju Chemical Co., Ltd. 0371-55900031 18137872243 2853979815@qq.com China 10019 55
Shanghai Dongyang Biotechnology Co., Ltd. 0512-0512-13601744364 13601744364 chemsharker@126.com China 879 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 psaitong@jm-bio.com China 29778 58
Supplier Advantage
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Tianjin Kailiqi Biotechnology Co., Ltd. 55
ShangHai Biochempartner Co.,Ltd 62
Shanghai Chaolan Chemical Technology Center 58
MQ (shanghai) Pharmaceuticals Co., Ltd. 55
Zhengzhou Huiju Chemical Co., Ltd. 55
Shanghai Dongyang Biotechnology Co., Ltd. 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
4(3H)-Pyrimidinone, 6-methyl-2-[[2-(1-naphthalenyl)-2-oxoethyl]thio]- I3MT-3 13MT-3 6-Methyl-2-((2-(naphthalen-1-yl)-2-oxoethyl)thio)pyrimidin-4(3H)-one 6-Methyl-2-((2-(naphthalen-1-yl)-2-oxoethyl)thio)pyrimidin-4(3H)-one[I3MT-3 HMPSNE EA.hy926 cells,Hippo (MST),inhibit,I3MT-3,3MST,HEK293,I3MT3,cell-membrane,COS-7,I-3MT-3,I3MT 3,Inhibitor 459420-09-8