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ChemicalBook >> CAS DataBase List >>1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]- Structure
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]- structure
CAS No.
2140807-23-2
Chemical Name:
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-
Synonyms
H-Isoindole-1;Thalidomide-NH-PEG3-OH;Pomalidomide-NH-PEG3-OH;Thalidomide-NH-C2-PEG3-OH;6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-;2-(2,6-dioxo-3-piperidyl)-4-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethylamino]isoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-4-((2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)amino)isoindoline-1,3-dione;H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-;1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-;inhibit,Inhibitor,Thalidomide-NH-C-2-PEG3-OH,E3 Ligase Ligand-Linker Conjugates,Thalidomide NH C2 PEG3 OH,ThalidomideNHC2PEG3OH
CBNumber:
CB18376658
Molecular Formula:
C21H27N3O8
Molecular Weight:
449.45
MDL Number:
MFCD32903299
MOL File:
2140807-23-2.mol
Last updated:2024-04-01 13:48:23
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1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]- Properties

Boiling point 706.3±60.0 °C(Predicted)
Density 1.390±0.06 g/cm3(Predicted)
pka 10.74±0.40(Predicted)

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]- Chemical Properties,Uses,Production

Biological Activity

Thalidomide-NH-C2-PEG3-OH is an E3 ligase ligand-linker conjugate that incorporates Thalidomide based cereblon ligand and a linker used for PROTAC BCL-XL degrader XZ739[1]. XZ739, a CRBN-dependent PROTAC BCL-XL degrader with a DC50 value of 2.5 nM in MOLT-4 cells after 16 h treatment. XZ739 also induces cell death through caspase-mediated apoptosis[1].

References

[1]. Xuan Zhang,et al. Discovery of PROTAC BCL-X L Degraders as Potent Anticancer Agents With Low On-Target Platelet Toxicity. Eur J Med Chem. 2020 Apr 15;192:112186.

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]- Suppliers

Global( 17)Suppliers
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TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203 info@chemextension.com China 42057 58
Xian confluore Biological Technology Co., Ltd. 		+86-15680926068 +86-15680926068 1924344760@confluore.cn China 2996 58
Suzhou ARTK Medchem Co., Ltd. 		+86-512-68323967 +86-18015559028 sales1@artkmedchem.com China 39009 58
Amatek Scientific Co. Ltd. 0512-56316828 info@amateksci.com China 28821 58
Xi'an Confluore Biological Technology Co., Ltd. +86-156-80926068 +86-15680926068 1924344760@qq.com China 4824 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1296 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9414 58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd 0431-80514535 19917294565 caoy@chemextension.com China 2977 58
Bide Pharmatech Ltd. 400-1647117 15221909166 product02@bidepharm.com China 63720 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58
Xian confluore Biological Technology Co., Ltd. 		58
Suzhou ARTK Medchem Co., Ltd. 		58
Amatek Scientific Co. Ltd. 58
Xi'an Confluore Biological Technology Co., Ltd. 58
Jilin Province Woda Biotechnology Co., Ltd. 58
DC Chemicals 58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd 58
Bide Pharmatech Ltd. 58

View Lastest Price from 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pomalidomide-NH-PEG3-OH pictures 2024-04-02 Pomalidomide-NH-PEG3-OH
2140807-23-2
 US $0.00 / mg 100mg >98.00% 100mg Xian confluore Biological Technology Co., Ltd.

2140807-23-2(1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]-)Related Search:

Acetaldehyde, 2-[2-[2-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]ethoxy]- Thalidomide-NH-PEG6-OH 1H-Isoindole-1,3(2H)-dione, 4-[(13,13-dioxido-3,6,9,12-tetraoxa-13-thiatetradec-1-yl)amino]-2-(2,6-dioxo-3-piperidinyl)-
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]- Thalidomide-NH-PEG3-OH 2-(2,6-dioxopiperidin-3-yl)-4-((2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)amino)isoindoline-1,3-dione Pomalidomide-NH-PEG3-OH 6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]- H-Isoindole-1 Thalidomide-NH-C2-PEG3-OH H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl]amino]- inhibit,Inhibitor,Thalidomide-NH-C-2-PEG3-OH,E3 Ligase Ligand-Linker Conjugates,Thalidomide NH C2 PEG3 OH,ThalidomideNHC2PEG3OH 2-(2,6-dioxo-3-piperidyl)-4-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethylamino]isoindoline-1,3-dione 2140807-23-2 C21H27N3O8