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SHP099 (hydrochloride)

SHP099 (hydrochloride) Structure
SHP099 (hydrochloride) structure
CAS No.
2200214-93-1
Chemical Name:
SHP099 (hydrochloride)
Synonyms
SHP-099,SHP 099,SHP099 hydrochloride,Inhibitor,Phosphatase,inhibit,SHP-099 hydrochloride,SHP099
CBNumber:
CB19043898
Molecular Formula:
C16H20Cl3N5
Molecular Weight:
388.72
MDL Number:
MFCD30343849
MOL File:
2200214-93-1.mol
Last updated:2023-09-04 15:51:00
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SHP099 (hydrochloride) Properties

solubility DMSO:41.05(Max Conc. mg/mL);105.6(Max Conc. mM)
Methanol:25.0(Max Conc. mg/mL);64.31(Max Conc. mM)
Water:4.25(Max Conc. mg/mL);10.93(Max Conc. mM)

SHP099 (hydrochloride) Chemical Properties,Uses,Production

Description

SHP099 is a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor with IC50 =0.07 μM and p-ERK modulation in cells IC50 = 0.250 μM. SHP099 exhibits dose-dependent pathway inhibition and antitumor activity in xenograft models. SHP2 is a nonreceptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also purportedly plays an important role in the programmed cell death pathway (PD-1/PD-L1). Because it is an oncoprotein associated with multiple cancer-related diseases, as well as a potential immunomodulator, controlling SHP2 activity is of significant therapeutic interest.

target

SHP2 inhibitor with IC50 =0.07 μM.

SHP099 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

SHP099 (hydrochloride) Suppliers

Global( 10)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 4009686088 3193328036@qq.com China 29796 68
Dezhou LonWel Pharmaceutical Technology Co., Ltd. 13761310616 39324283@qq.com China 1971 58
Chunchuang (Wuhan) Technology Co., Ltd 15342225168 yutianchun2007@126.com China 10000 58
Kaifeng Mingren Pharmaceutical Co.,LTD 0371-65741762 sales@hasunny.com China 2380 58
Wuhan Shanhai Zhihe Biotechnology Co., Ltd. 17771424646 shoubull@126.com China 966 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24018 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9180 58
Supplier Advantage
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
TargetMol Chemicals Inc. 		58
Beijing Solarbio Science & Tecnology Co., Ltd. 68
Dezhou LonWel Pharmaceutical Technology Co., Ltd. 58
Chunchuang (Wuhan) Technology Co., Ltd 58
Kaifeng Mingren Pharmaceutical Co.,LTD 58
Wuhan Shanhai Zhihe Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
RD International Technology Co., Limited 58

SHP099 (hydrochloride) Spectrum

SHP099 (hydrochloride)(2200214-93-1)1HNMR

2200214-93-1(SHP099 (hydrochloride))Related Search:

SHP099 SHP099 (hydrochloride)
SHP-099,SHP 099,SHP099 hydrochloride,Inhibitor,Phosphatase,inhibit,SHP-099 hydrochloride,SHP099 2200214-93-1