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TM608
- CAS No.
- 1956343-52-4
- Chemical Name:
- TM608
- Synonyms
- TM608;TM-608;TM 608
- CBNumber:
- CB211075864
- Molecular Formula:
- C43H37BrCl2N3O4PS
- Molecular Weight:
- 873.62
- MDL Number:
- MOL File:
- 1956343-52-4.mol
Last updated:2023-03-31 09:12:59
TM608 Chemical Properties,Uses,Production
Description
TM608 is a potent and selectiv c-MET inhibitor which targets Mitochondrial and Kills Erlotinib-Resistant Lung Cancer Cells. TM608 is the first TPP-TKI conjugate, can rapidly accumulates in mitochondria and suppresses the activation of MET in high MET expressing, erlotinib-resistant HCC827B cells (total cell lysates and mitochondrial fractions). TM608 was as potent and apoptogenic as PHA665752 in abrogating NSCLC cell viability. Directed accessibility to the mitochondria as afforded by a targeting moiety like TPP could conceivably compensate for deficient activity if uptake is rapid, cumulative, and selective.
TM608 Preparation Products And Raw materials
Raw materials
Preparation Products
TM608 Suppliers
Global( 1)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
TM 608
TM608
TM-608
1956343-52-4