8-Azaguanosine
- CAS No.
- 2133-80-4
- Chemical Name:
- 8-Azaguanosine
- Synonyms
- Azaguanosine;8-Azaguanosine;5-Amino-3,6-dihydro-3-β-D-ribofuranosyl-7H-v-triazolo[4,5-d]pyrimidin-7-one;5-Amino-3,6-dihydro-3-β-D-ribofuranosyl-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-one;7H-1,2,3-Triazolo[4,5-d]pyrimidin-7-one, 5-amino-3,6-dihydro-3-β-D-ribofuranosyl-;5-Amino-3,4-dihydro-3-(β-D-ribofuranosyl)-7H-1,2,3-triazolo[4,5-d]pyrimidin-7-one
- CBNumber:
- CB21245105
- Molecular Formula:
- C9H12N6O5
- Molecular Weight:
- 284.23
- MDL Number:
- MFCD01678077
- MOL File:
- 2133-80-4.mol
| Melting point | 250-252 °C (decomp)(Solv: water (7732-18-5)) |
|---|---|
| Density | 2.49±0.1 g/cm3(Predicted) |
| pka | 8.32±0.20(Predicted) |
| InChI | InChI=1/C9H12N6O5/c10-9-12-5-2(6(18)13-9)11-1-15(5)8-4(17)3(16)7(14-19)20-8/h1,3-4,7-8,14,16-17,19H,(H3,10,12,13,18)/t3-,4+,7-,8+/s3 |
| InChIKey | DGHTWAQOVOJABA-BKVVLWDVNA-N |
| SMILES | ON[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)N=C2)[C@H](O)[C@@H]1O |&1:2,4,16,18,r| |
8-Azaguanosine Chemical Properties,Uses,Production
Uses
8-Azaguanosine is an azapurine nucleoside.An extensive study has been made of the fluorescence emission properties of the neutral and ionic forms in aqueous medium of the 8-Azaguanosine. The 8-?azaguanosine is a substrate of purine nucleoside phosphorylase (PNP)?.
Definition
8-Azaguanosine (azaG) could replace specifically guanosine in the GpUpU codon for valine or the GpCpU codon for alanine in the stimulation of the binding of [14C]aminoacyl-tRNA to ribosomes. However, the binding efficiency in the presence of azaG-containing triplets was lower than in the presence of the natural codons. AzaG could replace guanosine in the 5'-position of codons for valine, alanine, and aspartic acid, as well as in the second position of codons for arginine. However, the template activity of azaG-containing triplets is lower than that of "normal" codons[1].
References
[1] D. Grünberger, F. ?orm, A. Holy?. “Synthesis and coding properties of 8-azaguanosinecontaining triribonucleoside diphosphates.” Biochimica et Biophysica Acta-Bioenergetics 31 1 (1968): 147–55.
8-Azaguanosine Preparation Products And Raw materials
Raw materials
Preparation Products
8-Azaguanosine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PANNACEAN(HENAN)MEDICINE SCIENCE TECHNOLOGIES LTD | 0371-55159968 18137130222 | haifeng.zhang@pannacean.com | China | 409 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10247 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 9976 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9900 | 58 |
| Jinan Yaoyan Pharmaceutical Co., Ltd. | jnyaoyan@163.com | China | 3069 | 58 | |
| Zhengzhou Granlen Sciences, ltd. | 0371-85513397 | info@granlen.com | China | 1842 | 58 |