saikogenin A
- CAS No.
- 5092-09-1
- Chemical Name:
- saikogenin A
- Synonyms
- Clinopodiside A1;Oleana-11,13(18)-diene-3,16,23,28-tetrol, (3β,4α,16β)-;Saikogenin A,inhibit,Inhibitor,DPP,1166100,Dipeptidyl Peptidase
- CBNumber:
- CB21340129
- Molecular Formula:
- C30H48O4
- Molecular Weight:
- 472.7
- MDL Number:
- MFCD00238674
- MOL File:
- 5092-09-1.mol
saikogenin A Chemical Properties,Uses,Production
Biological Activity
Saikogenin A, extracted from the traditional Chinese medicine Bupleurum, is a dipeptidyl peptidase IV (DPP-IV) inhibitor.
in vitro
Saikogenin A has certain inhibitory effect on the enzyme DPP-IV. At a concentration of 20 μg/mL DPP-IV inhibition is 47.6%. DPP-IV is a non-classical serine aminopeptidase from its amino terminus of polypeptides and proteins (N-terminus) removing Xaa-Pro dipeptide.
in vivo
Saikogenin A, an anti-inflammatory drug, is present in the crude extract of a Chinese herbal plant called Tsai-Fu. It is less effective in adrenalectomized rats than in normal rats in reducing the carrageenin-induced edema . The anti-inflammatory action of it are due to an increase in corticosterone caused by the release of arenocorticotropic hormone (ACTH) and a direct effect on the process of inflammation.
target
DPP-IV
saikogenin A Preparation Products And Raw materials
Raw materials
Preparation Products
saikogenin A Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632 | sales@reading-chemicals.com | China | 15185 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29796 | 68 |
| Chengdu Push Bio-Technology Co., Ltd. | 028-85370565-229 18080489829 | 3004654993@qq.com | China | 9217 | 60 |
| Chengdu Glip Biotechnology Co., Ltd. | 028-87075086 18030859262 | 2851503756@qq.com | China | 1922 | 58 |
| Chengdu Gupte Biotechnology Co., Ltd. | 13881890404 | 2851503757@qq.com | China | 2283 | 58 |