Minaprine dihydrochloride
- CAS No.
- 25953-17-7
- Chemical Name:
- Minaprine dihydrochloride
- Synonyms
- Ag 620;Agr 620;Agr 1240;Nsc305742;4-Methyl-N-(2-morpholinoethyl)-6-phenylpyridazin-3-amine dihydrochloride;Monoamine Oxidase,MAO,Minaprine dihydrochloride,inhibit,Inhibitor,Minaprine;Pyridazine, 4-methyl-3-[(2-morpholinoethyl)amino]-6-phenyl-, dihydrochloride;4-Morpholineethanamine, N-(4-methyl-6-phenyl-3-pyridazinyl)-, dihydrochloride;Morpholine, 4-[2-[(4-methyl-6-phenyl-3-pyridazinyl)amino]ethyl]-, dihydrochloride
- CBNumber:
- CB21485680
- Molecular Formula:
- C17H24Cl2N4O
- Molecular Weight:
- 371.30466
- MDL Number:
- MFCD00083410
- MOL File:
- 25953-17-7.mol
| Melting point | 182° |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMSO : ≥ 100 mg/mL (269.32 mM) |
| EWG's Food Scores | 1 |
| FDA UNII | 82Y7NT6DFT |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| Toxicity | LD50 intraperitoneal in mouse: 63mg/kg |
Minaprine dihydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-4347 | Minaprine dihydrochloride 99.61% | 25953-17-7 | 100mg | $60 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FM158555 | Minaprine dihydrochloride | 25953-17-7 | 500mg | $80 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FM158555 | Minaprine dihydrochloride | 25953-17-7 | 1g | $125 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FM158555 | Minaprine dihydrochloride | 25953-17-7 | 2g | $200 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0003396 | MINAPRINE DIHYDROCHLORIDE 95.00% | 25953-17-7 | 10MG | $280.35 | 2021-12-16 | Buy |
Minaprine dihydrochloride Chemical Properties,Uses,Production
Originator
Cantor,Clin Midy,France,1979
Uses
Antidepressant.
Manufacturing Process
(a) Preparation of the free base: A mixture comprising 0.1 mol (20.4 g) of 3-chloro-4-methyl-6-phenylpyridazine and 0.2 mol (26.2 g) of N-(2-aminoethyl)-morpholine in 100 ml of n-butanol, with a pinch of copper powder, was heatedunder reflux for 12 hours. At the end of this time, the hot solution was pouredinto 200 ml of cold water. The resulting mixture was filtered through asintered glass filter and the precipitate washed with ether. The filtrate and theether washings were placed in a separating funnel and extracted with two 150ml portions of ether. The ethereal layer was then extracted with about 250 mlof N sulfuric acid.
The acid solution was made alkaline with a 10% aqueous solution of sodiumcarbonate, and left to crystallize overnight.
The solution was filtered, yielding the colorless needles which wererecrystallized from isopropanol. The yield was 15 g (53%).
(b) Preparation of the hydrochloride: The base was dissolved in the smallestamount possible of anhydrous acetone. Double that volume of anhydrousether was added, and a stream of hydrogen chloride gas was passed throughthe solution. The hydrochloride salt obtained was recrystallized from absolutealcohol. The yield after recrystallization was 17 g (90%).
Therapeutic Function
Antidepressant
Minaprine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Minaprine dihydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3423 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai Luofa Biochemical Technology Co., Ltd. | 021-51111890 15317326293 | sales@molnova.com | China | 4196 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 29778 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 15221909166 | product02@bidepharm.com | China | 63720 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9180 | 58 |