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CAY10566

CAY10566 Structure
CAY10566 structure
CAS No.
944808-88-2
Chemical Name:
CAY10566
Synonyms
CAY10566;Inhibitor,inhibit,Stearoyl-CoA Desaturase (SCD),CAY10566,CAY 10566,CAY-10566;2-(6-(4-(2-CHLORO-5-FLUOROPHENOXY)PIPERIDIN-1-YL)PYRIDAZIN-3-YL)-5-METHYL-1,3,4-OXADIAZOLE;3-[4-(2-CHLORO-5-FLUOROPHENOXY)-1-PIPERIDINYL]-6-(5-METHYL-1,3,4-OXADIAZOL-2-YL)-PYRIDAZINE;Pyridazine, 3-[4-(2-chloro-5-fluorophenoxy)-1-piperidinyl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)-
CBNumber:
CB22468453
Molecular Formula:
C18H17ClFN5O2
Molecular Weight:
389.81
MDL Number:
MFCD11976899
MOL File:
944808-88-2.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:07
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CAY10566 Properties

Melting point 160 - 170°C
Boiling point 600.2±65.0 °C(Predicted)
Density 1.369±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
pka 2.01±0.10(Predicted)
form Solid
color Pale Beige

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

CAY10566 price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML3223 CAY10566 ≥98% (HPLC) 944808-88-2 5MG $201 2024-03-01 Buy
Sigma-Aldrich SML3223 CAY10566 ≥98% (HPLC) 944808-88-2 25MG $810 2024-03-01 Buy
Cayman Chemical 10012562 CAY10566 ≥98% 944808-88-2 1mg $79 2024-03-01 Buy
Cayman Chemical 10012562 CAY10566 ≥98% 944808-88-2 5mg $296 2024-03-01 Buy
Cayman Chemical 10012562 CAY10566 ≥98% 944808-88-2 10mg $553 2024-03-01 Buy
Product number Packaging Price Buy
SML3223 5MG $201 Buy
SML3223 25MG $810 Buy
10012562 1mg $79 Buy
10012562 5mg $296 Buy
10012562 10mg $553 Buy

CAY10566 Chemical Properties,Uses,Production

Description

Stearoyl-CoA desaturase (SCD) catalyzes the committed step of the conversion of saturated, long-chain fatty acids to monounsaturated fatty acids. The SCD1 gene is thought to play a key role in lipid homeostasis and body weight regulation. Thus, modulating SCD1 activity pharmacologically may be a useful tool for regulating type 2 diabetes, dyslipidemia, and obesity. CAY10566 is a potent and selective inhibitor of SCD1 that demonstrates IC50 values of 4.5 and 26 nM in mouse and human enzymatic assays, respectively. This compound inhibits the conversion of saturated, long-chain fatty acyl-CoAs to monounsaturated, long-chain fatty acyl-CoAs in HepG2 cells with IC50 values of 7.9 and 6.8 nM, respectively, when heptadecanoic acid and palmitic acid are used as the substrate.

Uses

CAY10566, is a stearoyl-CoA desaturase (SCD) inhibitor.

CAY10566 synthesis

3827-49-4
944808-88-2
Synthesis of CAY10566 from 2-Chloro-5-fluorophenol

CAY10566 Preparation Products And Raw materials

Raw materials

1-(6-Chloro-3-pyridazinyl)-4-piperidinol 2-Chloro-5-fluorophenol

Preparation Products

CAY10566 Suppliers

Global( 49)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32686 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43348 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203 info@chemextension.com China 42057 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3422 58
SPIRO PHARMA eric_feng1954@126.com China 9254 55
BOC Sciences 16314854226 info@bocsci.com United States 9926 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
InvivoChem 		58
LEAPCHEM CO., LTD. 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58
Aladdin Scientific 		58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
SPIRO PHARMA 55
BOC Sciences 65
Shanghai EFE Biological Technology Co., Ltd. 58
3-[4-(2-CHLORO-5-FLUOROPHENOXY)-1-PIPERIDINYL]-6-(5-METHYL-1,3,4-OXADIAZOL-2-YL)-PYRIDAZINE CAY10566 2-(6-(4-(2-CHLORO-5-FLUOROPHENOXY)PIPERIDIN-1-YL)PYRIDAZIN-3-YL)-5-METHYL-1,3,4-OXADIAZOLE Pyridazine, 3-[4-(2-chloro-5-fluorophenoxy)-1-piperidinyl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)- Inhibitor,inhibit,Stearoyl-CoA Desaturase (SCD),CAY10566,CAY 10566,CAY-10566 944808-88-2 C18H17ClFN5O2