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ChemicalBook >> CAS DataBase List >>N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide

N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide

N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide Structure
N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide structure
CAS No.
1190378-57-4
Chemical Name:
N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide
Synonyms
CS-2840;MRT68921;MRT67307;MRT67307 HCl;MRT67307 (free base);MRT67307 hydrochloride;MRT67307 HCl(free-base);IKKε/TBK1 Inhibitor II, MRT67307 - CAS 1190378-57-4 - Calbiochem;N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide;Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]-
CBNumber:
CB22547040
Molecular Formula:
C26H36N6O2
Molecular Weight:
464.6
MDL Number:
MFCD19443643
MOL File:
1190378-57-4.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:21
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N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide Properties

Density 1.270
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility H2O: soluble15mg/mL, clear
form powder
pka 15.94±0.20(Predicted)
color white to light brown
InChIKey UKBGBACORPRCGG-UHFFFAOYSA-N
FDA UNII MEY37JZ4XR

SAFETY

Risk and Safety Statements

WGK Germany  3

N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0702 MRT67307 hydrochloride ≥98% (HPLC) 1190378-57-4 5mg $134 2024-03-01 Buy
Sigma-Aldrich SML0702 MRT67307 hydrochloride ≥98% (HPLC) 1190378-57-4 25mg $543 2024-03-01 Buy
Sigma-Aldrich 5.06306 IKKε/TBK1 Inhibitor II, MRT67307 - CAS 1190378-57-4 - Calbiochem 1190378-57-4 5mg $209 2024-03-01 Buy
Cayman Chemical 19916 MRT67307 ≥95% 1190378-57-4 1mg $32 2024-03-01 Buy
Cayman Chemical 19916 MRT67307 ≥95% 1190378-57-4 5mg $100 2024-03-01 Buy
Product number Packaging Price Buy
SML0702 5mg $134 Buy
SML0702 25mg $543 Buy
5.06306 5mg $209 Buy
19916 1mg $32 Buy
19916 5mg $100 Buy

N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide Chemical Properties,Uses,Production

Uses

MRT67307 hydrochloride has been used to study its effect on LPS (lipopolysaccharide) -induced lysosome tubulation.

Definition

ChEBI: N-[3-[[5-cyclopropyl-2-[3-(4-morpholinylmethyl)anilino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide is an aromatic amine.

Biochem/physiol Actions

MRT67307 is an amino-pyrimidine derivative and has an IC50 value of 19. It is known to induce TLR (toll like receptor) mediated anti inflammatory cytokine generation. Also, MRT67307 prevents the secretion of cytokines associated with proinflammation.

target

IKKe

N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide Suppliers

Global( 86)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32686 60
Shandong chuangyingchemical Co., Ltd. 		18853181302 sale@chuangyingchem.com CHINA 5909 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49391 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
GIHI CHEMICALS CO.,LIMITED 		+8618058761490 info@gihichemicals.com China 50000 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 18223 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+undefined18621343501 product@acmec-e.com China 33350 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Shandong chuangyingchemical Co., Ltd. 		58
BOC Sciences 		58
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
InvivoChem 		58
GIHI CHEMICALS CO.,LIMITED 		58
Henan Fengda Chemical Co., Ltd 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58

N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide Spectrum

N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide(1190378-57-4)1HNMR
MRT67307 MRT67307 hydrochloride N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]-cyclobutanecarboxamide hydrochloride MRT68921 N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide MRT67307 (free base) IKKε/TBK1 Inhibitor II, MRT67307 - CAS 1190378-57-4 - Calbiochem MRT67307 HCl CS-2840 Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]- MRT67307 HCl(free-base) 1190378-57-4 C26H36N6O2xHCl NF-kB API