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AZ191

AZ191 structure

CAS No.: 1594092-37-1

Chemical Name:: AZ191

Synonyms: AZ191;CS-1824;AZ-191;AZ 191;N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1h-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine;2-Pyrimidinamine, N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-;[2-Methoxy-4-(4-methyl-piperazin-1-yl)-phenyl]-[4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-pyrimidin-2-yl]-amine;Inhibitor,AZ-191,Dual specificity tyrosine regulated kinase,AZ191,Dual specificity tyrosine phosphorylation regulated kinase,inhibit,AZ 191,DYRK;N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1h-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine, AZ191

CBNumber:: CB22716123

Molecular Formula:: C24H27N7O

Molecular Weight:: 429.52

MDL Number:: MFCD28015098

MOL File:: 1594092-37-1.mol

Last updated:2023-06-30 15:45:59

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AZ191 Properties

Boiling point	705.3±70.0 °C(Predicted)
Density	1.29±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility	DMSO: soluble10mg/mL, clear
form	powder
pka	7.76±0.42(Predicted)
color	white to yellow to light brown

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301-H227
Precautionary statements	P501-P270-P210-P264-P280-P370+P378-P301+P310+P330-P403+P235-P405
WGK Germany	3

AZ191 price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	17693	AZ191 ≥98%	1594092-37-1	1mg	$32	2024-03-01	Buy
Cayman Chemical	17693	AZ191 ≥98%	1594092-37-1	5mg	$109	2024-03-01	Buy
Cayman Chemical	17693	AZ191 ≥98%	1594092-37-1	10mg	$199	2024-03-01	Buy
Cayman Chemical	17693	AZ191 ≥98%	1594092-37-1	25mg	$456	2024-03-01	Buy
Tocris	5232	AZ191 ≥98%(HPLC)	1594092-37-1	50	$836	2021-12-16	Buy

Product number	Packaging	Price	Buy
17693	1mg	$32	Buy
17693	5mg	$109	Buy
17693	10mg	$199	Buy
17693	25mg	$456	Buy
5232	50	$836	Buy

AZ191 Chemical Properties,Uses,Production

Uses

AZ191 is a potent and selective DYRK1B inhibitor (1).

Enzyme inhibitor

This potent and selective DYRK inhibitor (FW = 429.53 g/mol), also systematically named N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)-4- (1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine, selectively targets DYRK1B, a Dual specificity tyrosine-phosphorylation-regulated kinase, with an IC50 value of 17 nM, or about 5x and 110x higher affinity than for DYRK1A and DYRK2. AZ191 is effective both in vitro and in cells. DYRK1B has also been proposed to promote the turnover of Cyclin D1, a key regulator of mammalian G1-S-phase transitions. Cyclin D1 is phosphorylated on Thr-286 by GSK3β (or glycogen synthase kinase 3β), thereby promoting its degradation.

storage

Store at -20°C

AZ191 Preparation Products And Raw materials

Raw materials

Preparation Products

AZ191 Suppliers

Global( 76)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
InvivoChem	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58

View Lastest Price from AZ191 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	AZ191 1594092-37-1	US $1.00 / KG	1KG	98-100%	1000kg	Career Henan Chemical Co

AZ191
1594092-37-1
US $1.00 / KG
98-100%
Career Henan Chemical Co

AZ191 Spectrum

AZ191(1594092-37-1)¹HNMR

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N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1h-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine, AZ191 [2-Methoxy-4-(4-methyl-piperazin-1-yl)-phenyl]-[4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-pyrimidin-2-yl]-amine AZ191 AZ-191;AZ 191 CS-1824 N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1h-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine 2-Pyrimidinamine, N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)- Inhibitor,AZ-191,Dual specificity tyrosine regulated kinase,AZ191,Dual specificity tyrosine phosphorylation regulated kinase,inhibit,AZ 191,DYRK 1594092-37-1 C24H27N7O Inhibitors