5-tert-butoxyquinazoline-2,4-diaMine
- CAS No.
- 1009734-33-1
- Chemical Name:
- 5-tert-butoxyquinazoline-2,4-diaMine
- Synonyms
- HZ-1157;HZ 1157;HZ1157;DHFR-inhibitor;5-tert-butoxyquinazoline-2,4-diaMine;2,4-Quinazolinediamine, 5-(1,1-dimethylethoxy)-;HCV,Inhibitor,HZ-1157,inhibit,virus,HCV Protease,HZ 1157,dengue;5-tert-butoxyquinazoline-2,4-diaMine 2,4-Quinazolinediamine, 5-(1,1-dimethylethoxy)-
- CBNumber:
- CB22727774
- Molecular Formula:
- C12H16N4O
- Molecular Weight:
- 232.28
- MDL Number:
- MFCD22666183
- MOL File:
- 1009734-33-1.mol
- MSDS File:
- SDS
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
|---|---|
| solubility | insoluble in H2O; ≥11.6 mg/mL in DMSO; ≥8.82 mg/mL in EtOH |
| form | solid |
| NCI Dictionary of Cancer Terms | DHFR inhibitor |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P280-P305+P351+P338-P310 |
5-tert-butoxyquinazoline-2,4-diaMine price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23436 | HZ-1157 ≥98% | 1009734-33-1 | 5mg | $30 | 2024-03-01 | Buy |
| Cayman Chemical | 23436 | HZ-1157 ≥98% | 1009734-33-1 | 1mg | $118 | 2023-06-20 | Buy |
| ApexBio Technology | A8898 | HZ-1157 | 1009734-33-1 | 5mg | $350 | 2021-12-16 | Buy |
| AK Scientific | 1426DC | 5-Tert-butoxyquinazoline-2,4-diaMine | 1009734-33-1 | 5mg | $634 | 2021-12-16 | Buy |
| ApexBio Technology | A8898 | HZ-1157 | 1009734-33-1 | 25mg | $1200 | 2021-12-16 | Buy |
5-tert-butoxyquinazoline-2,4-diaMine Chemical Properties,Uses,Production
Biological Activity
hz-1157 is a potent hepatitis c virus (hcv) inhibitor toward hcv ns3/4a protease with ic50 value of 1.0 μmol/l [1].the ns3 protease of hcv is a prime target for the development of anti-hcv agents because it cleaves the viral polyprotein and liberates ns3, ns4a, ns4b, ns5a, and ns5b, allowing them to function normally in viral rna replication, and it deactivates many host proteins involved in innate immunity to foster a favorable cellular environment for hcv replication. the ns3 protease is most active when complexed with its cofactor ns4a [1].
in vitro
huh7.5.1 cell line stably transfected with hcv ns3/4a protease reporter was established to investigate the anti-hcv mechanism of hz-1157 (0.001~1 μmol/l). the results showed that hz-1157 exhibited inhibitory effect on the hcv ns3/4a protease with ic50 value of 1.0 μmol/l. hz-1157 was further tested against an infectious hcv virus (j399em) which can infect and replicate in huh7.5.1 cells in vitro. the results showed that hz-1157 effectively inhibited j399em virus replication in huh7.5.1 cells with ic50 value of 0.82 μmol/l [1].
References
[1]. yu y, jing j, tong x, et al. discovering novel anti-hcv compounds with inhibitory activities toward hcv ns3/4a protease[j]. acta pharmacologica sinica, 2014, 35(8): 1074.
5-tert-butoxyquinazoline-2,4-diaMine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
| Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |