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TAPI-1

TAPI-1 structure

CAS No.: 171235-71-5

Chemical Name:: TAPI-1

Synonyms: TAP 1;CS-1499;(S,S)-TAPI-1;(2S,2S)-TAPI-1;TAPI-1 TFA Salt;2-aminoethyl Amide;TAPI-1 trifluoroacetate;TNF-α Protease Inhibitor-1;TNF-Α PROTEASE INHIBITOR-1 (TAPI-1);N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine

CBNumber:: CB22729657

Molecular Formula:: C26H37N5O5

Molecular Weight:: 499.6

MDL Number:: MFCD02684280

MOL File:: 171235-71-5.mol

Last updated:2023-05-18 11:30:59

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TAPI-1 Properties

Density	1?+-.0.06 g/cm3(Predicted)
storage temp.	-20C
solubility	≥24.98 mg/mL in DMSO; ≥15.77 mg/mL in EtOH with ultrasonic; ≥18.1 mg/mL in H2O
form	White solid
pka	9.17±0.20(Predicted)

TAPI-1 price More Price(13)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	579051	TAPI-1 - CAS 171235-71-5 - Calbiochem TAPI-1, CAS 171235-71-5, is a structural analog of TAPI-0 with similar in vitro efficacy for the inhibition of MMPs and TACE. Blocks the shedding of several cell surface proteins.	171235-71-5	1mg	$475	2024-03-01	Buy
Cayman Chemical	18505	TAPI-1 ≥98%	171235-71-5	500μg	$149	2024-03-01	Buy
Cayman Chemical	18505	TAPI-1 ≥98%	171235-71-5	1mg	$253	2024-03-01	Buy
Cayman Chemical	18505	TAPI-1 ≥98%	171235-71-5	5mg	$894	2024-03-01	Buy
Usbiological	493389	TAP1	171235-71-5	100ul	$529	2021-12-16	Buy

Product number	Packaging	Price	Buy
579051	1mg	$475	Buy
18505	500μg	$149	Buy
18505	1mg	$253	Buy
18505	5mg	$894	Buy
493389	100ul	$529	Buy

TAPI-1 Chemical Properties,Uses,Production

Uses

TAPI-1 Trifluoroacetic Acid Salt is a TNF-a converting enzyme (TACE) inhibitor, which blocks shedding of cytokine receptors. It is a modulation of juxtamembrane cleavage (shedding) of angiotensin-converting enzyme by stalking glycosylation in relation to an alternative shedding protease.

General Description

A structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE (TNF-α convertase; ADAM17). However, TAPI-1 is more stable in serum than TAPI-0. TAPI-1 Blocks the shedding of several cell surface proteins such as TNF-α, IL-6 receptor, and p60 and p80 TNF receptors. Inhibits constitutive (IC₅₀ = 8.09 μM) and muscarinic receptor-stimulated (IC₅₀ = 3.61 μM) sAPPa release in HEK-293 cells expressing muscarinic receptors. Also blocks the TACE-dependent constitutive release of co-transfected APP(695) (IC₅₀ = 920 nM).

Biological Activity

tapi-1 is an inhibitor of tumour necrosis factor with ic50 value of 8.09 μm [1].tapi-1 is an inhibitor of tace/adam17 which catalyzes the cleavage of full-length app to the soluble n-terminal fragment (sappα). the release of sappα has been reported to be a receptor-coupled process increased by the stimulation of muscarinic receptors. in hek293 cells, treatment of tapi-1 resulted in an inhibition of increased sappα which was induced by the expressing of m3 subtype. the ic50 values of tapi-1 in the inhibition of m3-increased sappα and constitutive release of sappα were 3.61 μm and 8.09 μm, respectively. besides app, tapi-1 was also found to have inhibitory effects on the release of tnf-α, il6r, tnfri and tnfrii with ic50 values of 50-100, 5-10, 5-10 and 25-50 mm, respectively [1, 2].

Biochem/physiol Actions

Primary TargetMMPs and TACE

References

[1] slack b, ma l, seah c. constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-α converting enzyme. biochem. j, 2001, 357: 787-794.
[2] hooper n, karran e, turner a. membrane protein secretases. biochem. j, 1997, 321: 265-279.

TAPI-1 Preparation Products And Raw materials

Raw materials

Preparation Products

TAPI-1 Suppliers

Global( 57)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alpha Biopharmaceuticals Co., Ltd	+86-411-39042497 +8613921981412	sales@alphabiopharm.com	China	886	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19915	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Alabiochem Tech.Co., Ltd.	0512-58900862 400-0707518	sales@alabiochem.com	China	995	59

Supplier	Advantage
Alpha Biopharmaceuticals Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Nextpeptide Inc	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Alabiochem Tech.Co., Ltd.	59

TAPI-1 Spectrum

TAPI-1(171235-71-5)¹HNMR

171235-71-5(TAPI-1)Related Search:

DAPT PD 151746 VX-661

N1-((S)-1-((S)-1-(2-aminoethylamino)-1-oxopropan-2-ylamino)-3-(naphthalen-2-yl)-1-oxopropan-2-yl)-N4-hydroxy-2-isobutylsuccinamide N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-L-alaninamide N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)-L-alaninamide TAPI-1 TAPI-1 trifluoroacetate TNF-Α PROTEASE INHIBITOR-1 (TAPI-1) 2-aminoethyl Amide N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-NAPHTHYLALANYL-L-ALANINE; 2-AMINOETHYL AMIDE; TNF-Α PROTEASE INHIBITOR-1 TNF-α Protease Inhibitor-1 (2S,2S)-TAPI-1 CS-1499 TAP 1 L-Alaninamide, N-[2-[2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-N-(2-aminoethyl)- (9CI) TAPI-1 TFA Salt (S,S)-TAPI-1 171235-71-5 C26H37N5O5 Inhibitors