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ChemicalBook >> CAS DataBase List >>2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide

2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide

2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide Structure
2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide structure
CAS No.
313254-51-2
Chemical Name:
2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide
Synonyms
ICA-121431;ICA-121431 >=98% (HPLC);ICA-121431;ICA 121431;ICA121431;2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl;2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide;2,2-DIPHENYL-N-(4-(N-THIAZOL-2-YLSULFAMOYL)PHENYL) ACETAMIDE;α-Phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-benzeneacetamide;Benzeneacetamide, α-phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-;alpha-Phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]benzeneacetamide;Nav,Na channels,inhibitor,ICA-121431,ICA 121431,TTX-resistant,Sodium Channel,channel,Na+ channels,ICA121431,inhibit
CBNumber:
CB22737166
Molecular Formula:
C23H19N3O3S2
Molecular Weight:
449.55
MDL Number:
MFCD00992334
MOL File:
313254-51-2.mol
Last updated:2023-09-04 16:42:00
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2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide Properties

Density 1.409±0.06 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: soluble20mg/mL, clear
pka 7.03±0.10(Predicted)
form powder
color white to beige
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey URSQNPPONHUJDL-UHFFFAOYSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H319-H413
Precautionary statements  P273-P301+P312+P330-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22-36
Safety Statements  26
WGK Germany  3
NFPA 704
0
2 0

2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1035 ICA-121431 ≥98% (HPLC) 313254-51-2 5mg $120 2024-03-01 Buy
Sigma-Aldrich SML1035 ICA-121431 ≥98% (HPLC) 313254-51-2 25mg $190.4 2024-03-01 Buy
Cayman Chemical 24669 ICA 121431 ≥98% 313254-51-2 1mg $32 2024-03-01 Buy
Cayman Chemical 24669 ICA 121431 ≥98% 313254-51-2 5mg $109 2024-03-01 Buy
Cayman Chemical 24669 ICA 121431 ≥98% 313254-51-2 10mg $199 2024-03-01 Buy
Product number Packaging Price Buy
SML1035 5mg $120 Buy
SML1035 25mg $190.4 Buy
24669 1mg $32 Buy
24669 5mg $109 Buy
24669 10mg $199 Buy

2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide Chemical Properties,Uses,Production

Description

ICA 121431 is a voltage-gated sodium channel (Nav) blocker that selectively blocks Nav1.1 and Nav1.3 over Nav1.4, and Nav1.5-1.8 channels (IC50s = <20, 19, 240, and >10,000 nM, respectively). It induces a concentration-dependent hyperpolarizing shift in voltage dependence of inactivation of Nav1.3 channels at a concentration 1 μM but has no effect on resting channels. Substitution of the Nav1.3 domain IV voltage-sensor domain (VSD4) with the Nav1.5 VSD4 reduces ICA 121431 potency by approximately 500-fold.

Uses

ICA 121431 is a voltage-gated sodium (Nav) channel inhibitor.

storage

+4°C

References

McCormack et al. (2013), Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels; Proc. Natl. Acad. Sci. USA 110 E2724 Ostenn et al. (2017), Pharmacology of the Nav1.1 domain IV voltage sensor reveals coupling between inactivation gating processes; Proc. Natl. Acad. Sci. USA 114 6836

2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide Suppliers

Global( 53)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2923 55
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 6010 61
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7553 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4863 58
Supplier Advantage
career henan chemical co 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
Shanghai Boyle Chemical Co., Ltd. 55
Chembest Research Laboratories Limited 61
Haoyuan Chemexpress Co., Ltd. 61
MedChemexpress LLC 58

View Lastest Price from 2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Benzeneacetamide, α-?phenyl-?N-?[4-?[(2-?thiazolylamino)?sulfonyl]?phenyl]?- pictures 2020-01-10 Benzeneacetamide, α-?phenyl-?N-?[4-?[(2-?thiazolylamino)?sulfonyl]?phenyl]?-
313254-51-2
 US $0.01 / KG 1KG 98%; 99% 500g;1kg； 25kg Career Henan Chemical Co

2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide Spectrum

2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide(313254-51-2)1HNMR

313254-51-2(2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide)Related Search:

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ICA-121431 2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide α-Phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-benzeneacetamide alpha-Phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]benzeneacetamide 2,2-DIPHENYL-N-(4-(N-THIAZOL-2-YLSULFAMOYL)PHENYL) ACETAMIDE ICA-121431;ICA 121431;ICA121431 Benzeneacetamide, α-phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]- 2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl ICA-121431 >=98% (HPLC) Nav,Na channels,inhibitor,ICA-121431,ICA 121431,TTX-resistant,Sodium Channel,channel,Na+ channels,ICA121431,inhibit 313254-51-2