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DBCO-NHS Ester

CAS No.
1353016-71-3
Chemical Name:
DBCO-NHS Ester
Synonyms
N-Succinimidyl 4-[(5-Aza-3,4:7,8-dibenzocyclooct-1-yne)-5-yl]-4-oxobutyrate;DBCO-NHS;DBCO-NHS ester;CAS_1353016-71-3;DBCO-NHS ester (DBCO NHS ester);4-[(5-aza-3,4:7,8-dibenzocyclooctan-1-yne)-5-yl]-4-oxobutyrate-n-succinimide;2,5-Dioxo-1-pyrrolidinyl-11,12-didehydro-γ-oxodibenz[b,f]azocine-5(6H)-butanoate;11,12-Didehydro-γ-oxo-dibenz[b,f]azocine-5(6H)-butanoic acid 2,5-dioxo-1-pyrrolidinyl ester;Dibenz[b,f]azocine-5(6H)-butanoic acid, 11,12-didehydro-γ-oxo-, 2,5-dioxo-1-pyrrolidinyl ester;Dibenz[b,?f]azocine-5(6H)-butanoic acid,11,12-didehydro-γ-oxo-,2,5-dioxo-1-pyrrolidinyl ester (DBCO-NHS)
CBNumber:
CB23146567
Molecular Formula:
C23H18N2O5
Molecular Weight:
402.4
MDL Number:
MFCD24386367
MOL File:
1353016-71-3.mol
Last updated:2024-03-20 19:26:33

DBCO-NHS Ester Properties

Boiling point 670.2±65.0 °C(Predicted)
Density 1.43±0.1 g/cm3(Predicted)
solubility Soluble in DMSO, DCM, DMF
pka -0.23±0.20(Predicted)
form Solid
color White to Off-White
Stability Moisture Sensitive

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  29339900

DBCO-NHS Ester price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC D194965 DBCO-NHSEster 1353016-71-3 1mg $50 2021-12-16 Buy
Chem-Impex 33411 DBCO-NHSester,98%(HPLC) 98%(HPLC) 1353016-71-3 5MG $112 2021-12-16 Buy
BroadPharm BP-22231 DBCO-NHS 97% 1353016-71-3 50mg $140 2021-12-16 Buy
Chem-Impex 33411 DBCO-NHSester,98%(HPLC) 98%(HPLC) 1353016-71-3 25MG $212.8 2021-12-16 Buy
ChemScene CS-0021839 DBCO-NHSester 99.22% 1353016-71-3 100mg $215 2021-12-16 Buy
Product number Packaging Price Buy
D194965 1mg $50 Buy
33411 5MG $112 Buy
BP-22231 50mg $140 Buy
33411 25MG $212.8 Buy
CS-0021839 100mg $215 Buy

DBCO-NHS Ester Chemical Properties,Uses,Production

Description

DBCO-NHS Ester is a very popular amine-reactive click chemistry reagent. It can be used to modify an amine-containing molecule in organic solvents (limited solubility in aqueous media). It reacts with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. The low mass weight will add minimal spacer to modified molecules. DBCO is commonly used for copper-free Click Chemistry reactions.

Uses

DBCO NHS ester contains an NHS carbonate group and a DBCO group. The spacer contains a photocleavable nitrobenzyloxyl group, which can be efficiently cleaved under UV to release the conjugated molecules. DBCO on the other hand readily react with azide bearing biomolecule through a copper-free click reaction instantly and in high yield.
DBCO-NHS Ester is a very popular amine-reactive click chemistry reagent. It can be used to modify an amine-containing molecule in organic solvents (limited solubility in aqueous media). It reacts with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. The low mass weight will add minimal spacer to modified molecules. DBCO is commonly used for copper-free Click Chemistry reactions.

Uses

DBCO-NHS Ester is a derivative of DBCO (Dibenzylcyclooctyne), used in Cu-free click chemistry. It useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. Used in DNA-Assisted protein analysis such as proximity ligation and extention assays. Intracellular Imaging.

516-12-1
1353016-70-2
1353016-71-3
Synthesis of DBCO-NHS Ester from N-Iodosuccinimide and DBCO-Acid

DBCO-NHS Ester Suppliers

Global( 124)Suppliers
Supplier Tel Email Country ProdList Advantage
9i LLC
+18039569191 MWan@NiNeiLab.com United States 418 58
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32686 60
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Zhengzhou Alfa Chemical Co.,Ltd
+8618530059196 sale04@alfachem.cn China 12740 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Wuhan Borenpharm Co., Ltd
027-65563561 18717150066 3207347307@qq.com CHINA 1238 58
Career Henan Chemica Co
+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
GL Biochem (Shanghai) Ltd.
+86-021-61263370 +86-18901917034 CHINA 3904 58
Hangzhou Huarong Pharm Co., Ltd.
571-86758373 +8613588754946 sales@huarongpharm.com CHINA 3149 58

View Lastest Price from DBCO-NHS Ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
DBCO-NHS ester pictures 2024-03-20 DBCO-NHS ester
1353016-71-3
US $0.00 / mg 100mg >99.00% 1g Xian confluore Biological Technology Co., Ltd.
  • DBCO-NHS ester pictures
  • DBCO-NHS ester
    1353016-71-3
  • US $0.00 / mg
  • >99.00%
  • Xian confluore Biological Technology Co., Ltd.
DBCO-NHS DBCO-NHS ester (DBCO NHS ester) 11,12-Didehydro-γ-oxo-dibenz[b,f]azocine-5(6H)-butanoic acid 2,5-dioxo-1-pyrrolidinyl ester CAS_1353016-71-3 Dibenz[b,f]azocine-5(6H)-butanoic acid, 11,12-didehydro-γ-oxo-, 2,5-dioxo-1-pyrrolidinyl ester 4-[(5-aza-3,4:7,8-dibenzocyclooctan-1-yne)-5-yl]-4-oxobutyrate-n-succinimide N-Succinimidyl 4-[(5-Aza-3,4:7,8-dibenzocyclooct-1-yne)-5-yl]-4-oxobutyrate Dibenz[b,?f]azocine-5(6H)-butanoic acid,11,12-didehydro-γ-oxo-,2,5-dioxo-1-pyrrolidinyl ester (DBCO-NHS) DBCO-NHS ester (2,5-dioxopyrrolidin-1-yl) 4-(2-azatricyclo[10.4.0.0??]hexadeca-1(12),4(9),5,7,13,15-hexaen-10-yn-2-yl)-4-oxo-butanoate 2,5-Dioxo-1-pyrrolidinyl-11,12-didehydro-γ-oxodibenz[b,f]azocine-5(6H)-butanoate 1353016-71-3 ADC LINKER