ChemicalBook >> CAS DataBase List >>2'2'-cGAMP
2'2'-cGAMP
- CAS No.
- 1465774-27-9
- Chemical Name:
- 2'2'-cGAMP
- Synonyms
- 2'2'-cGAMP;2’2’-cGAMP (sodium salt);2'2'-cGAMP (sodium salt);2'-Guanylic acid, adenylyl-(2'→5')-, cyclic nucleotide;adenylyl-(2’→5’)-2’-guanylicacid,cyclicnucleotide,disodiumsalt
- CBNumber:
- CB23311738
- Molecular Formula:
- C20H24N10O13P2
- Molecular Weight:
- 674.411
- MDL Number:
- MOL File:
- 1465774-27-9.mol
Last updated:2023-05-21 10:59:17
2'2'-cGAMP price More Price(2)
2'2'-cGAMP Chemical Properties,Uses,Production
Description
2’2’-cGAMP is a synthetic dinucleotide (CDN) that contains non-canonical 2''5''-phosphodiester bonds. It binds to the adapter protein stimulator of interferon genes (STING; Item Nos. 22816 | 22815), which is a component of the innate immune response that activates the type I interferon pathway when bound to cyclic dinucleotides. 2’2-cGAMP shows weaker binding to STING than 2’3’-cGAMP (; Kd = 287 and 3.79 nM, respectively) but binds more strongly than 3’3’-cGAMP , cyclic di-GMP , or 3’2’-cGAMP, which bind in the micromolar range (Kds = 1.04, 1.21, or 1.61 μM, respectively). Despite weaker binding, 2’2’-cGAMP induces IFN-β production in the same concentration range as 2’3’-cGAMP (EC50s = 15.8 and 19.4 nM, respectively, in L929 cells).
2'2'-cGAMP Preparation Products And Raw materials
Raw materials
Preparation Products
2'2'-cGAMP Suppliers
Global( 10)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | sales@tybiochem.com | China | 5061 | 58 |
TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.com | China | 24246 | 58 |
2'2'-cGAMP
2’2’-cGAMP (sodium salt)
2'-Guanylic acid, adenylyl-(2'→5')-, cyclic nucleotide
adenylyl-(2’→5’)-2’-guanylicacid,cyclicnucleotide,disodiumsalt
2'2'-cGAMP (sodium salt)
1465774-27-9