ChemicalBook >> CAS DataBase List >>L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-

L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-

L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)- structure

CAS No.: 1948273-02-6

Chemical Name:: L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-

Synonyms: (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide;VHL ligand 2;E3 ligase Ligand 1A;CPD101077;(S,R,S)-AHPC-Me;E3 ligase Ligand 1 (free base);L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-;VHL ligand-2,VHL ligand2,Inhibitor,inhibit,Ligands for E3 Ligase,(S,R,S) AHPC Me,(S,R,S)AHPCMe,E3 ligase-recruiting Moiety;(2S,4R)-1-[(S)-2-Amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[(S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]pyrrolidine-2-carboxamide;(2S,4S)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-h ydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phen yl]ethyl]pyrrolidine-2-carboxamide

CBNumber:: CB23376069

Molecular Formula:: C23H32N4O3S

Molecular Weight:: 444.59

MDL Number:: MFCD31630815

MOL File:: 1948273-02-6.mol

Last updated:2023-12-19 14:03:52

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L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)- Properties

Boiling point	687.9±55.0 °C(Predicted)
Density	1.233±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	14.00±0.40(Predicted)
InChIKey	JOSFQWNOUSNZBP-UUZHKXTQSA-N
SMILES	C(N[C@H](C1=CC=C(C2SC=NC=2C)C=C1)C)(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](C(C)(C)C)N

L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)- price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biorbyt Ltd	orb611322	E3 ligase Ligand 1A >98%	1948273-02-6	500mg	$765	2021-12-16	Buy
Biorbyt Ltd	orb611322	E3 ligase Ligand 1A >98%	1948273-02-6	1g	$1133.9	2021-12-16	Buy
Biorbyt Ltd	orb611322	E3 ligase Ligand 1A >98%	1948273-02-6	2g	$1876.8	2021-12-16	Buy
Ambeed	A351331	(2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 97%	1948273-02-6	1g	$950	2021-12-16	Buy
Ambeed	A351331	(2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide 97%	1948273-02-6	50mg	$142	2021-12-16	Buy

Product number	Packaging	Price	Buy
orb611322	500mg	$765	Buy
orb611322	1g	$1133.9	Buy
orb611322	2g	$1876.8	Buy
A351331	1g	$950	Buy
A351331	50mg	$142	Buy

L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)- Chemical Properties,Uses,Production

Description

E3 Ligase ligand 1a is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. E3 Ligase ligand 1a can be used to synthesize ARV-771, a BET PROTAC degrader.

Uses

(4R)-3-Methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-L-prolinamide, is a ligand of E3 ligase,

L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)- Preparation Products And Raw materials

Raw materials

Preparation Products

L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)- Suppliers

Global( 55)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou Origin Specialty Chemicals Co., Ltd.	+86-512-68662322 +86-17312436797	hanqun@origsc.com	China	788	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	7154	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12740	58
Shenzhen Shengda Pharma Limited	755-85269922 +8613424394241	sales@shengdapharm.com	CHINA	310	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Sichuan Biosynce Pharmatech Co., Ltd.	+8619950309693	diane@biosynce.com	China	4874	58

Supplier	Advantage
Suzhou Origin Specialty Chemicals Co., Ltd.	58
ATK CHEMICAL COMPANY LIMITED	60
Jinan Carbotang Biotech Co.,Ltd.	58
BOC Sciences	58
Zhengzhou Alfa Chemical Co.,Ltd	58
Shenzhen Shengda Pharma Limited	58
InvivoChem	58
TargetMol Chemicals Inc.	58
LEAPCHEM CO., LTD.	58
Sichuan Biosynce Pharmatech Co., Ltd.	58

1948273-02-6(L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-)Related Search:

E3 ligase Ligand 18 E3 ligase Ligand 10 E3 ligase Ligand 14 rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine Cereblon Ligand 1

4-Hydroxy ThalidoMide Protein degrader 1 (TFA) (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione

1of2

L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)- CPD101077 (S,R,S)-AHPC-Me E3 ligase Ligand 1 (free base) (2S,4S)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-h ydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phen yl]ethyl]pyrrolidine-2-carboxamide E3 ligase Ligand 1A (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide VHL ligand 2 VHL ligand-2,VHL ligand2,Inhibitor,inhibit,Ligands for E3 Ligase,(S,R,S) AHPC Me,(S,R,S)AHPCMe,E3 ligase-recruiting Moiety (2S,4R)-1-[(S)-2-Amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[(S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]pyrrolidine-2-carboxamide (2S, 4R) -1- ((S) -2-amino-3,3-dimethylbutyryl) -4-hydroxy-N - ((S) -1- (4- (4-methylthiazol-5-yl) phenyl) ethyl) pyrrolidine-2-formamide 1948273-02-6