ChemicalBook >> CAS DataBase List >>C188-9
C188-9
- CAS No.
- 432001-19-9
- Chemical Name:
- C188-9
- Synonyms
- TTI-101;C188-9;F0808-0084;STAT3 inhibitor TTI-101;C 188-9;C-188-9;C-1889;C1889;C 1889;C-1889;F0808-0084;C188-9; C 188-9; C-188-9; C-1889; C1889; C 1889; C-1889; F0808-0084;N-(1',2-Dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide;N-(1',2-Dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide;N-(1',2-dihydroxy-1.2'-binaphthhalen-4'-yl)-4-methoxybenzene-sulphonamide;Benzenesulfonamide, N-(1',2-dihydroxy[1,2'-binaphthalen]-4'-yl)-4-methoxy-
- CBNumber:
- CB23959200
- Molecular Formula:
- C27H21NO5S
- Molecular Weight:
- 471.52
- MDL Number:
- MFCD03141581
- MOL File:
- 432001-19-9.mol
Last updated:2023-06-08 09:03:02
| Boiling point | 680.9±65.0 °C(Predicted) |
|---|---|
| Density | 1.416±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml |
| form | A crystalline solid |
| pka | 8.14±0.50(Predicted) |
| FDA UNII | KZ3DLD11RQ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
C188-9 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0044737 | C188-9 99.50% | 432001-19-9 | 5mg | $100 | 2021-12-16 | Buy |
| ChemScene | CS-0044737 | C188-9 99.50% | 432001-19-9 | 10mg | $140 | 2021-12-16 | Buy |
| ChemScene | CS-0044737 | C188-9 99.50% | 432001-19-9 | 25mg | $290 | 2021-12-16 | Buy |
| ChemScene | CS-0044737 | C188-9 99.50% | 432001-19-9 | 50mg | $460 | 2021-12-16 | Buy |
| ChemScene | CS-0044737 | C188-9 99.50% | 432001-19-9 | 100mg | $720 | 2021-12-16 | Buy |
C188-9 Chemical Properties,Uses,Production
Biological Activity
C188-9 (TTI 101) is a potent STAT3 inhibitor, binds STAT3 with high affinity, Kd=4.7±0.4 nM. It is well tolerated in mice, has good oral bioavailability, and is mainly enriched in tumor tissues.
in vitro
C188-9 is a small molecule inhibitor of STAT3, targeting the phosphotyrosine peptide binding site in the SH2 region of STAT3 with a Ki value of 136 nM. It does not inhibit upstream Jak or Src kinases.
in vivo
C188-9 inhibited tumor growth in mice bearing UM-SCC-17B xenografts after administration of C188-9. C188-9 was well tolerated in mice, had good oral bioavailability, and was concentrated in tumor tissue after administration.
target
| Target | Value |
| STAT3 (Cell-free) | 4.7 nM(Kd) |
C188-9 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 71)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5909 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4604 | 58 |
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 17702719238 | sales@sun-shinechem.com | China | 918 | 64 |
C188-9
C 188-9;C-188-9;C-1889;C1889;C 1889;C-1889;F0808-0084
N-(1',2-dihydroxy-1.2'-binaphthhalen-4'-yl)-4-methoxybenzene-sulphonamide
C188-9; C 188-9; C-188-9; C-1889; C1889; C 1889; C-1889; F0808-0084
F0808-0084
Benzenesulfonamide, N-(1',2-dihydroxy[1,2'-binaphthalen]-4'-yl)-4-methoxy-
N-(1',2-Dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide
TTI-101
C1889,Apoptosis,STAT,Inhibitor,C188 9,C-188-9,C188-9,TTI101,TTI 101,inhibit
STAT3 inhibitor TTI-101
N-(1',2-Dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide
432001-19-9