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DM3-Sme

DM3-Sme structure

CAS No.: 796073-70-6

Chemical Name:: DM3-Sme

Synonyms: DM3-Sme;Maytansine, N2'-deacetyl-N2'-[4-(methyldithio)-1-oxopentyl]- (9CI)

CBNumber:: CB23959871

Molecular Formula:: C38H54ClN3O10S2

Molecular Weight:: 812.43

MDL Number:: MFCD28400103

MOL File:: 796073-70-6.mol

Last updated:2023-05-21 10:59:17

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DM3-Sme Properties

Boiling point	962.6±65.0 °C(Predicted)
Density	1.31±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
pka	9.82±0.70(Predicted)

DM3-Sme price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0104944	DM3-SMe	796073-70-6	100mg	$4138	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0104944	100mg	$4138	Buy

DM3-Sme Chemical Properties,Uses,Production

Description

DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM[1][2].

References

[1]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8). [2]. Yuliang Zhaoet al. Biomedical Nanomaterials. 2016-‎Science.

DM3-Sme Preparation Products And Raw materials

Raw materials

Preparation Products

DM3-Sme Suppliers

Global( 3)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58

Supplier	Advantage
BOC Sciences	58
TargetMol Chemicals Inc.	58

DM3-Sme Maytansine, N2'-deacetyl-N2'-[4-(methyldithio)-1-oxopentyl]- (9CI) 796073-70-6 C38H54ClN3O10S2