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Methuosis inducer

Methuosis inducer structure

CAS No.: 2240205-30-3

Chemical Name:: Methuosis inducer

Synonyms: Methuosis inducer;Methuosis inducer 1;Inhibitor,Methuosis inducer 1,Methuosis inducer-1,inhibit,Methuosis inducer1;Benzamide, N-[4-methyl-3-[[6-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]amino]phenyl]-3-(trifluoromethyl)-

CBNumber:: CB24819512

Molecular Formula:: C27H20F3N5O

Molecular Weight:: 487.48

MDL Number:: MFCD31813674

MOL File:: 2240205-30-3.mol

Last updated:2023-05-21 10:59:17

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Methuosis inducer Properties

Density	1.399±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 25 mg/mL (51.28 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C)
pka	12.81±0.70(Predicted)

Methuosis inducer Chemical Properties,Uses,Production

Biological Activity

Methuosis inducer 1 is a potent methuosis inducer[1]. Anticancer activity[1]. Methuosis inducer 1 (Compound 13) shows a broad spectrum of cytotoxicity against a panel of human cancer cell lines with IC50 values of 0.326±0.026 μM, 1.370±0.061 μM, 1.662±0.128 μM, 1.892±0.092 μM, 1.571±0.066 μM, 2.268±0.100 μM, 2.611±0.739 μM, 1.008±0.042 μM, 1.566±0.015 μM, and 1.197±0.344 μM for A375, SK-MEL-28, SK-MEL-30, A549, MDA-MB-231, MDA-MB-435S, MCF-7, HCT116, BGC823, HepG2 cells, respectively[1].

References

[1]. Huang W, et al. Discovery and Identification of Small Molecules as Methuosis Inducers with in Vivo Antitumor Activities. J Med Chem. 2018 Jun 28;61(12):5424-5434.

Methuosis inducer Preparation Products And Raw materials

Raw materials

Preparation Products

Methuosis inducer Suppliers

Global( 8)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8011	62
Shanghai Rechem science Co., Ltd.	21-31433387 15618786686	sales@rechemscience.com	China	2993	58
Angel Pharmatech, Ltd.	17317130613	3358272972@qq.com	China	3244	58
Hubei Kele Fine Chemical Co., Ltd	027-59101668 19945030958	2881924765@qq.com	China	7977	58
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.	+86-027-59232304 15387063101	2881924050@qq.com	China	9892	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24018	58
Olix (Shanghai) Pharmaceutical Technology Co., Ltd	17316404525	209533805@qq.com	China	9621	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
ShangHai Biochempartner Co.,Ltd	62
Shanghai Rechem science Co., Ltd.	58
Angel Pharmatech, Ltd.	58
Hubei Kele Fine Chemical Co., Ltd	58
Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.	58
TargetMol Chemicals Inc.	58
Olix (Shanghai) Pharmaceutical Technology Co., Ltd	58

Methuosis inducer Methuosis inducer 1 Inhibitor,Methuosis inducer 1,Methuosis inducer-1,inhibit,Methuosis inducer1 Benzamide, N-[4-methyl-3-[[6-(3-pyridinyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]amino]phenyl]-3-(trifluoromethyl)- 2240205-30-3