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BMS-1166

BMS-1166 Structure
BMS-1166 structure
CAS No.
1818314-88-3
Chemical Name:
BMS-1166
Synonyms
BMS-1166;PD-1/PD-L1-IN1;BMS-1166 (PD-1/PD-L1-IN1);PD-1/PD-L1-IN1 BMS-1166;BMS-1166 (Synonyms: PD-1/PD-L1-IN1);BMS 1166Q: What is BMS 1166 Q: What is the CAS Number of BMS 1166;Inhibitor,BMS1166,BMS 1166,activation,immune,cell,interaction,BMS-1166,dimerization,checkpoint,inhibit;D-Proline, 1-[[5-chloro-2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]phenyl]methyl]-4-hydroxy-, (4R)-;(2R,4R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-hydroxypyrrolidine-2-carboxylic acid
CBNumber:
CB24843928
Molecular Formula:
C36H33ClN2O7
Molecular Weight:
641.11
MDL Number:
MFCD31746874
MOL File:
1818314-88-3.mol
Last updated:2023-05-21 10:59:17
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BMS-1166 Properties

Boiling point 817.5±65.0 °C(Predicted)
Density 1.42±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
form A crystalline solid
pka 2.03±0.40(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

BMS-1166 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0022454 BMS-1166 99.86% 1818314-88-3 5mg $550 2021-12-16 Buy
ChemScene CS-0022454 BMS-1166 99.86% 1818314-88-3 10mg $850 2021-12-16 Buy
ChemScene CS-0022454 BMS-1166 99.86% 1818314-88-3 25mg $1750 2021-12-16 Buy
ChemScene CS-0022454 BMS-1166 99.86% 1818314-88-3 50mg $2750 2021-12-16 Buy
ChemScene CS-0022454 BMS-1166 99.86% 1818314-88-3 100mg $3950 2021-12-16 Buy
Product number Packaging Price Buy
CS-0022454 5mg $550 Buy
CS-0022454 10mg $850 Buy
CS-0022454 25mg $1750 Buy
CS-0022454 50mg $2750 Buy
CS-0022454 100mg $3950 Buy

BMS-1166 Chemical Properties,Uses,Production

Biological Activity

BMS-1166 is a novel and potent inhibitor of PD-1/PD-L1 interaction with IC50 of 1.4 nM.

in vitro

BMS-1166 had low toxicity to the tested cell lines and prevented the interaction of soluble PD-L1 with PD-1 receptors expressed on the cell surface. It attenuates the inhibitory effect of PD-L1 on T cell receptor-mediated T lymphocyte activation.

target

TargetValue
PD-1/PD-L1 interaction
()		 1.4 nM

BMS-1166 Preparation Products And Raw materials

Raw materials

Preparation Products

BMS-1166 Suppliers

Global( 54)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32686 60
Career Henan Chemica Co 		+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
CR Corporation Lomited 		fred.wen@crcorporation.cn CHINA 12069 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8474 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 15317229551 15151849396@163.com China 997 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Career Henan Chemica Co 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
CR Corporation Lomited 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Aladdin Scientific 		58
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 58
PD-1/PD-L1-IN1 BMS-1166 (Synonyms: PD-1/PD-L1-IN1) D-Proline, 1-[[5-chloro-2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]phenyl]methyl]-4-hydroxy-, (4R)- PD-1/PD-L1-IN1 BMS-1166 BMS-1166 (PD-1/PD-L1-IN1) BMS 1166Q: What is BMS 1166 Q: What is the CAS Number of BMS 1166 (2R,4R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-hydroxypyrrolidine-2-carboxylic acid BMS-1166 Inhibitor,BMS1166,BMS 1166,activation,immune,cell,interaction,BMS-1166,dimerization,checkpoint,inhibit 1818314-88-3 C36H33ClN2O7