FMOC-ASP-ODMAB
- CAS No.
- 172611-77-7
- Chemical Name:
- FMOC-ASP-ODMAB
- Synonyms
- FMOC-ASP-ODMAB;Fmoc-L-Asp-ODmab;FMOC-ASP-ODMAB 5 G;(9H-Fluoren-9-yl)MethOxy]Carbonyl Asp-ODmab;Fmoc-L-aspartic acid α-4-[N-{1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl}amino]benzyl ester;Fmoc-L-aspartic acid alpha-4-[N-{1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl}amino]benzyl ester;FMOC-L-ASPARTIC ACID ALPHA-4-[N-[1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEXYLIDENE)-3-METHYLBUTYL]AMINO]BENZYL ESTER;N-ALPHA-FMOC-L-ASPARTIC ACID ALPHA-4-[N-[1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEXYLIDENE)-3-METHYLBUTYL]-AMINO] BENZYL ESTER;N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-aspartic acid 1-[[4-[[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]phenyl]methyl] ester;L-Aspartic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 1-[[4-[[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino]phenyl]methyl] ester
- CBNumber:
- CB2713809
- Molecular Formula:
- C39H42N2O8
- Molecular Weight:
- 666.76
- MDL Number:
- MFCD00797876
- MOL File:
- Mol file
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
FMOC-ASP-ODMAB price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.52079 | Fmoc-Asp-ODmab Novabiochem? | 172611-77-7 | 1G | $264 | 2023-06-20 | Buy |
| Sigma-Aldrich | 8.52079 | Fmoc-Asp-ODmab Novabiochem? | 172611-77-7 | 5G | $1050 | 2023-06-20 | Buy |
| Chem-Impex | 03693 | Fmoc-L-asparticacidα-4-[N-{1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl}amino]benzylester,98%(HPLC) 98%(HPLC) | 172611-77-7 | 25G | $2144.8 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | AAA0006777 | FMOC-ASP-ODMAB 95.00% | 172611-77-7 | 5MG | $503.1 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | AAA0006777 | FMOC-ASP-ODMAB 95.00% | 172611-77-7 | 250MG | $594 | 2021-12-16 | Buy |
FMOC-ASP-ODMAB Chemical Properties,Uses,Production
Chemical Properties
FMOC-ASP-ODMAB is Yellow powder
Uses
The Dmab group can be cleaved selectively in the presence of tBu-based protected groups by treatment with 2% hydrazine in DMF, making this derivative an extremely useful tool for the preparation of cyclic peptides by FMOC SPPS
General Description
Quasi-orthogonally-protected Asp derivative.
The Dmab group can be removed selectively in the presence of tBu-based protecting groups by treatment with 2% hydrazine in DMF [1], making this derivative an extremely useful tool for the preparation of cyclic peptides by Fmoc SPPS or for library synthesis.
Occasionally sluggish cleavage of the aminobenzyl moiety is observed [2, 3]. In these instances, washing the support with 20% DIPEA in DMF/water (9:1) [2] or HCl in dioxane [4] has been found to be efficacious.
For the on-resin synthesis of side-chain to side-chain lactam bridged peptides, the combination of Lys(ivDde) and Asp(ODmab) is particularly advantageous since both side-chains can be simultaneously unmasked in a single step.
To avoid aspartimide formation, it is advisable to employ an Hmb- or Dmb-protected derivative for introduction of the preceding residue.
For applications of this derivative in the synthesis of cyclic peptides, see references [5 - 7].
The product number for this product was previously 04-12-1176.
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FMOC-ASP-ODMAB Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alpha Biopharmaceuticals Co., Ltd | +86-411-39042497 +8613921981412 | sales@alphabiopharm.com | China | 886 | 58 |
| GL Biochem (Shanghai) Ltd. | +86-021-61263370 +86-18901917034 | CHINA | 3904 | 58 | |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Alabiochem Tech.Co., Ltd. | 0512-58900862 400-0707518 | sales@alabiochem.com | China | 996 | 59 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shenzhen Chim Biotech Co., Ltd. | 0755-36320761 13692196024 | sales@chimchem.com | China | 501 | 55 |
| Shanghai GL Peptide Ltd. | +86-21-61263310; 13764994101 13764994101 | fisherwang@glschina.com | China | 8465 | 55 |
| Supplier | Advantage |
|---|---|
| Alpha Biopharmaceuticals Co., Ltd | 58 |
| GL Biochem (Shanghai) Ltd. | 58 |
| BOC Sciences | 58 |
| Nextpeptide Inc | 58 |
| Aladdin Scientific | 58 |
| Alabiochem Tech.Co., Ltd. | 59 |
| GL Biochem (Shanghai) Ltd | 64 |
| Sigma-Aldrich | 80 |
| Shenzhen Chim Biotech Co., Ltd. | 55 |
| Shanghai GL Peptide Ltd. | 55 |