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EST64454

EST64454 Structure
EST64454 structure
CAS No.
1950569-11-5
Chemical Name:
EST64454
Synonyms
EST64454;EST64454 HCl;EST64454 hydrochloride;pain,Inhibitor,EST 64454,EST64454 hydrochloride,nerve,selective,EST-64454 hydrochloride,Sigma Receptor,EST-64454,oral,inhibit
CBNumber:
CB28210252
Molecular Formula:
C18H23ClF2N4O2
Molecular Weight:
400.85
MDL Number:
MFCD33023223
MOL File:
1950569-11-5.mol
Last updated:2023-09-20 16:43:00
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EST64454 Properties

storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (249.47 mM; Need ultrasonic)

EST64454 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0144561 EST64454hydrochloride 99.19% 1950569-11-5 5mg $350 2021-12-16 Buy
ChemScene CS-0144561 EST64454hydrochloride 99.19% 1950569-11-5 10mg $550 2021-12-16 Buy
ChemScene CS-0144561 EST64454hydrochloride 99.19% 1950569-11-5 25mg $950 2021-12-16 Buy
ChemScene CS-0144561 EST64454hydrochloride 99.19% 1950569-11-5 50mg $1450 2021-12-16 Buy
ChemScene CS-0144561 EST64454hydrochloride 99.19% 1950569-11-5 100mg $2250 2021-12-16 Buy
Product number Packaging Price Buy
CS-0144561 5mg $350 Buy
CS-0144561 10mg $550 Buy
CS-0144561 25mg $950 Buy
CS-0144561 50mg $1450 Buy
CS-0144561 100mg $2250 Buy

EST64454 Chemical Properties,Uses,Production

Biological Activity

EST64454 hydrochloride is a selective and orally active sigma-1 receptor antagonist with a Ki of 22 nM. EST64454 hydrochloride has the potential for the research of the pain[1]. EST64454 (10 mg/kg; p.o.; male Wistar rats) treatment shows the Cmax, t1/2, AUC0-∞, Vss and F% are 771 ng/mL, 3.4 hours, 1431 ng h/mL, 4.4 l/kg and 69%, respectively[1].EST64454 (10 mg/kg; p.o.; male CD1 mice) treatment shows the Cmax, t1/2, AUC0-∞, Vss and F% were 1178 ng/mL, <1 hours, 2645 ng h/mL, 1.2 l/kg and 60%, respectively[1].

References

[1]. Díaz JL, et al. EST64454: a Highly Soluble σ1 Receptor Antagonist Clinical Candidate for Pain Management. J Med Chem. 2020;63(23):14979-14988.

EST64454 Preparation Products And Raw materials

Raw materials

Preparation Products

EST64454 Suppliers

Global( 12)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32686 60
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8474 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 9767 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9414 58
Wuhan Augda Biotechnology Co., Ltd 15071299552 262933239@qq.com China 6637 58
InvivoChem 13549236410 sales@invivochem.cn China 6713 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24018 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Aladdin Scientific 		58
Shanghai Chaolan Chemical Technology Center 58
DC Chemicals 58
Wuhan Augda Biotechnology Co., Ltd 58
InvivoChem 58
TargetMol Chemicals Inc. 58

EST64454 Spectrum

EST64454(1950569-11-5)1HNMR
EST64454 EST64454 hydrochloride EST64454 HCl pain,Inhibitor,EST 64454,EST64454 hydrochloride,nerve,selective,EST-64454 hydrochloride,Sigma Receptor,EST-64454,oral,inhibit 1950569-11-5