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ChemicalBook >> CAS DataBase List >>9H-Carbazole-9-acetamide, N-(2-chloro-6-cyanophenyl)-

9H-Carbazole-9-acetamide, N-(2-chloro-6-cyanophenyl)-

9H-Carbazole-9-acetamide, N-(2-chloro-6-cyanophenyl)- Structure
9H-Carbazole-9-acetamide, N-(2-chloro-6-cyanophenyl)- structure
CAS No.
1801856-93-8
Chemical Name:
9H-Carbazole-9-acetamide, N-(2-chloro-6-cyanophenyl)-
Synonyms
KL044;KL-044;KL 044;9H-Carbazole-9-acetamide, N-(2-chloro-6-cyanophenyl)-
CBNumber:
CB28369158
Molecular Formula:
C21H14ClN3O
Molecular Weight:
359.81
MDL Number:
MFCD33548809
MOL File:
1801856-93-8.mol
Last updated:2023-05-21 10:59:17
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9H-Carbazole-9-acetamide, N-(2-chloro-6-cyanophenyl)- Properties

Boiling point 563.3±50.0 °C(Predicted)
Density 1.30±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (277.92 mM; Need ultrasonic)
pka 11.00±0.70(Predicted)

9H-Carbazole-9-acetamide, N-(2-chloro-6-cyanophenyl)- Chemical Properties,Uses,Production

Biological Activity

KL044, a stabilizer of the clock protein cryptochrome (CRY) , is a potent chemical probe with a pEC50 value of 7.32, leading to the extension of the circadian period and repression of Per2 activity[1]. KL044 (0-3.7 μM; 8 h) effectively stabilizes the CRY1-LUC fusion protein without affecting the stability of LUC in the HEK293 stable cell line[1].

References

[1]. Jae Wook Lee, et al. Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock. ChemMedChem. 2015 Sep;10(9):1489-97.

9H-Carbazole-9-acetamide, N-(2-chloro-6-cyanophenyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

9H-Carbazole-9-acetamide, N-(2-chloro-6-cyanophenyl)- Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24018 58
Supplier Advantage
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TargetMol Chemicals Inc. 58
9H-Carbazole-9-acetamide, N-(2-chloro-6-cyanophenyl)- KL 044 KL044 KL-044 1801856-93-8