ChemicalBook >> CAS DataBase List >>1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo-

1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo-

1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo- structure

CAS No.: 1644626-43-6

Chemical Name:: 1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo-

Synonyms: TDRL551;TDRL 551;TDRL-551;TDRL 551,TDRL551;1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo-

CBNumber:: CB28693460

Molecular Formula:: C25H23ClIN3O4

Molecular Weight:: 591.83

MDL Number:

MOL File:: 1644626-43-6.mol

Last updated:2023-05-21 10:59:17

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1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo- Properties

Boiling point	704.0±70.0 °C(Predicted)
Density	1.62±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 62.5 mg/mL (105.60 mM; Need ultrasonic)
pka	4.65±0.10(Predicted)

1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo- Chemical Properties,Uses,Production

Biological Activity

TDRL-551 is a potent replication protein A (RPA) inhibitor (IC50=18 μM). TDRL-551 inhibits RPA-DNA interaction and increases the efficacy of Platinum (Pt)-based chemotherapy in lung and ovarian cancer. RPA plays essential roles in both nucleotide excision repair (NER) and homologous recombination (HR), along with its role in DNA replication and DNA damage checkpoint activation[1].

References

[1]. Mishra AK, et al. Chemical inhibitor targeting the replication protein A-DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer. Biochem Pharmacol. 2015;93(1):25-33.

1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo- Suppliers

Global( 4)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Block Chemical Technology (Shanghai) Co., Ltd.	021-20432219 13918097649	li_jinfei@acblock-lab.com	China	9913	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24018	58
Nantong QuanYi Biotechnology Co., Ltd	0513-66337626 18051384581	sales@chemhifuture.com	China	4164	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Block Chemical Technology (Shanghai) Co., Ltd.	58
TargetMol Chemicals Inc.	58
Nantong QuanYi Biotechnology Co., Ltd	58

1H-Pyrazole-1-pentanoic acid, 5-(2-chloro-7-ethoxy-3-quinolinyl)-4,5-dihydro-3-(4-iodophenyl)-δ-oxo- TDRL 551 TDRL551 TDRL-551 TDRL 551,TDRL551 1644626-43-6 C25H23ClIN3O4