17-GMP-APA-GA
- CAS No.
- Chemical Name:
- 17-GMP-APA-GA
- Synonyms
- 17-GMP-APA-GA
- CBNumber:
- CB29399475
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
17-GMP-APA-GA Chemical Properties,Uses,Production
Description
17-GMP-APA-GA is an analog of geldanamycin (Cat.# 10-1084) equipped with linker for coupling to proteins or antibodies for the preparation of immunoconjugates, for example.
Uses
17-GMP-APA-GA is an analog of geldanamycin(G304500) with modified linker for coupling proteins/antibodies for the preparation of immunoconjugates.
References
1) Mandler et al. (2004), Herceptin-geldanamycin immunoconjugates: pharmacokinetics, biodistribution, and enhanced antitumor activity; Cancer Res., 64 1460 2) Mandler et al. (2002), Modifications in synthesis strategy improve the yield and efficacy of geldanamycin-herceptin immunoconjugates; Bioconj. Chem., 13 786 3) Mandler et al. (2000), Immunoconjugates of geldanamycin and anti-HER2 monoclonal antibodies: antiproliferative activity on human breast carcinoma cell lines; J. Natl. Cancer Inst., 92 1573
17-GMP-APA-GA Preparation Products And Raw materials
Raw materials
Preparation Products
17-GMP-APA-GA Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Focus Biomolecules | -- | sales@focusbiomolecules.com | United States | 1284 | 58 |
| Supplier | Advantage |
|---|---|
| Focus Biomolecules | 58 |