Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]-
![Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]- Structure](CAS/20210305/GIF/2227482-41-7.gif)
- CAS No.
- 2227482-41-7
- Chemical Name:
- Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]-
- Synonyms
- ELOVL1-27;ELOVL1-IN-1;ELOVL1-IN-27;Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]-;1-(2-Fluorophenyl)-N-(1-(2-fluoropyridin-4-YL)-1H-pyrazol-3-YL)cyclopropane-1-carboxamide;chain,inhibit,adrenoleukodystrophy,Inhibitor,ELOVL1IN1,ALD,fatty,ELOVL-1-IN-1,acid,ELOVL1 IN 1,long
- CBNumber:
- CB310022981
- Molecular Formula:
- C18H14F2N4O
- Molecular Weight:
- 340.33
- MDL Number:
- MOL File:
- 2227482-41-7.mol
Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]- Properties
| Boiling point | 584.1±50.0 °C(Predicted) |
|---|---|
| Density | 1.40±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: insol; DMSO: 2 mg/ml; Ethanol: insol; PBS (pH 7.2): insol |
| form | A crystalline solid |
| pka | 12.79±0.20(Predicted) |
Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]- Chemical Properties,Uses,Production
Biological Activity
ELOVL1-IN-1 is an ELOVL1 inhibitor extracted from patent WO2018107056A1, compound 87. ELOVL1-IN-1 can reduce very long chain fatty acid levels. ELOVL1-IN-1 can be used for the research of adrenoleukodystrophy (ALD)[1]. ELOVL1-IN-1 (compound 87) (1 nM-10 μM; 48 h) reduces the the level of VLCFA, lysophosphatidylcholine (LPC) in adrenoleukodystrophy (ALD) patient fibroblasts and healthy human fibroblasts, ALD patient B‐lymphocytes, and human microglia[1]. ELOVL1-IN-1 (compound 87) reduces of a VLCFA level, specifically C26:0 LPC level in blood of ABCD1 knockout (KO) mice (0.5-64 mg/kg; p.o. once daily for 28 days), wild‐type (WT) rats (30-300 mg/kg; p.o. once daily for 7 days), and cynomolgous monkeys (30 mg/kg; p.o. once daily for 7 days)[1].
References
[1]. Charifson PS, et, al. 1,3-substitued pyrazole compounds useful for reduction of very long chain fatty acic levels. WO2018107056A1.
Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]- Preparation Products And Raw materials
Raw materials
Preparation Products
Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd | 15317229551 | 15151849396@163.com | China | 997 | 58 |
| Hangzhou Taorui Biotechnology Co., Ltd | 4000-360-990 15268198094 | sales@torreybio.com | China | 2659 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9180 | 58 |