Grepafloxacin hydrochloride
- CAS No.
- 161967-81-3
- Chemical Name:
- Grepafloxacin hydrochloride
- Synonyms
- Gpfx;Raxar;D02178;Raxar (tn);DSSTox_CID_26692;DSSTox_RID_81826;GREPAFLOXACIN HCL;DSSTox_GSID_46692;Grepafloxacin hydrochloride;Grepafloxacin hydrochloride USP/EP/BP
- CBNumber:
- CB31011738
- Molecular Formula:
- C19H22FN3O3
- Molecular Weight:
- 395.86
- MDL Number:
- MFCD00903717
- MOL File:
- 161967-81-3.mol
- MSDS File:
- SDS
| storage temp. | Store at -20°C |
|---|---|
| solubility | H2O : ≥ 13.33 mg/mL (33.67 mM) |
| FDA UNII | A4ER1Z8N9N |
Grepafloxacin hydrochloride Chemical Properties,Uses,Production
Originator
Raxar,Glaxo Wellcome,UK
Uses
Antibacterial.
Uses
Grepafloxacin Hydrochloride is a useful compound for treatment of ophthalmic and otic infections.
Manufacturing Process
To 3-(3-methyl-1-piperazinyl)-4-fluoro-5-methyl-6-nitro-N-cyclopropylaniline is
added diethyl ethoxymethylenemalonate and the mixture is heated at 150°C
for 25 hours. After cooling, the reaction product is purified by silica-gel
column-chromatography (dichloromethane:methanol = 100:1) to give
diethyl[N-cyclopropyl-N-[3-(3-methyl-1-piperazinyl)-4-fluoro-5-methyl-6-nitrophenyl] aminomethylene]malonate. The product is dissolved in acetic
anhydride and thereto conc. sulfuric acid is added dropwise at 50-60°C,
followed by stirring for 30 min. The mixture is poured into ice-water,
neutralized, extracted with dichloromethane and the extract is dried. The
solvent is distilled off under reduced pressure. Purification by silica-gel
column-chromatography (dichloromethane:methanol = 10:1) to give ethyl 7-
(3-methyl-1-piperazinyl)-1-cyclopropyl-6-fluoro-5-methyl-1,4-dihydro-4-
oxoquinoline-3-carboxylate. To these compound is 10% aqueous solution of
sodium hydroxide and ethanol, and the mixture is refluxed for 1 hour. After
cooling, the reaction mixture is diluted with water and washed with
dichloromethane. The aqueous layer is made acidic with acetic acid and then
made weakly alkaline with an aqueous sodium hydrogen carbonate. The
product is extracted with dichloromethane and the extract is dried. The
solvent is distilled off under reduced pressure and to the residue is added
ethanol. The precipitated crystals are filtered and recrystallized from DMFA to
give 7-(3-methyl-1-piperazinyl)-1-cyclopropyl-6-fluoro-5-methyl-1,4-dihydro-
4-oxoquinoline-3-carboxylic acid (12 mg), as white powder, m.p. 206-208°C.
7-(3-methyl-1-piperazinyl)-1-cyclopropyl-6-fluoro-5-methyl-1,4-dihydro-4-
oxoquinoline-3-carboxylicacid may be transformed to hydrochloride.
brand name
Raxar (Otsuka).
Therapeutic Function
Antibacterial
Grepafloxacin hydrochloride Preparation Products And Raw materials
Grepafloxacin hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28200 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |
| Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 021-59167510 18117107507 | vip@med-life.cn | China | 5019 | 58 |
View Lastest Price from Grepafloxacin hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-22 | Grepafloxacin hydrochloride USP/EP/BP
161967-81-3
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2019-12-20 | Grepafloxacinhydrochloride
161967-81-3
|
US $0.00 / KG | 1KG | 99% | kg/T | Career Henan Chemical Co |
-
- Grepafloxacin hydrochloride USP/EP/BP
161967-81-3
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Grepafloxacinhydrochloride
161967-81-3
- US $0.00 / KG
- 99%
- Career Henan Chemical Co