3-amino-4,5-dihydroxy-5-[[1-(8-hydroxy-1-oxo-isochroman-3-yl)-3-methyl -butyl]carbamoyl]pentanoic acid
![3-amino-4,5-dihydroxy-5-[[1-(8-hydroxy-1-oxo-isochroman-3-yl)-3-methyl -butyl]carbamoyl]pentanoic acid Structure](CAS/GIF/82768-33-0.gif)
- CAS No.
- 82768-33-0
- Chemical Name:
- 3-amino-4,5-dihydroxy-5-[[1-(8-hydroxy-1-oxo-isochroman-3-yl)-3-methyl -butyl]carbamoyl]pentanoic acid
- Synonyms
- Amicoumacin B;3-amino-4,5-dihydroxy-5-[[1-(8-hydroxy-1-oxo-isochroman-3-yl)-3-methyl -butyl]carbamoyl]pentanoic acid
- CBNumber:
- CB31257442
- Molecular Formula:
- C20H28N2O8
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- 82768-33-0.mol
3-amino-4,5-dihydroxy-5-[[1-(8-hydroxy-1-oxo-isochroman-3-yl)-3-methyl -butyl]carbamoyl]pentanoic acid Chemical Properties,Uses,Production
Biological Activity
Amicoumacin B is an amicoumacin that has been found in N. jinanensis and has quorum-sensing inhibitory activity.1 It is active against C. violaceum (MIC = 250 μg/ml) and reduces the expression of the C. violaceum operons vioA, vioB, vioD, and vioE, but increases the expression of vioC, indicating quorum sensing inhibitory activity.2 Amicoumacin B increases the expression of bone morphogenetic protein 2 (BMP2) in MG-63 cells.1,3
References
1.Sun, W., Zhang, Y.-Q., Huang, Y., et al.Nocardia jinanensis sp. nov., an amicoumacin B-producing actinomyceteInt. J. Syst. Evol. Microbiol.59(Pt 2)417-420(2009) 2.Shi, W.-P., Zeng, H., Wan, C.-X., et al.Amicoumacins from a desert bacterium: quorum sensing inhibitor against Chromobacterium violaceumNat. Prod. Res.(2020) 3.Zhao-Yong, Y., Zhi-Fei, Z., Xiao-Bo, H., et al.Study on the effect of amicoumacin B on up-regulating bmp-2 transcription and expression in MG63 cellsChin. J. Antibiot.33(4)203-205(2008)
3-amino-4,5-dihydroxy-5-[[1-(8-hydroxy-1-oxo-isochroman-3-yl)-3-methyl -butyl]carbamoyl]pentanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3-amino-4,5-dihydroxy-5-[[1-(8-hydroxy-1-oxo-isochroman-3-yl)-3-methyl -butyl]carbamoyl]pentanoic acid Suppliers
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| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
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