PC 766B
- CAS No.
- 108375-77-5
- Chemical Name:
- PC 766B
- Synonyms
- PC 766B;Oxacyclohexadeca-3,5,11,13-tetraen-2-one, 16-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-4-[(2,6-dideoxy-β-D-arabino-hexopyranosyl)oxy]tetrahydro-2-hydroxy-5-methyl-6-[(1E,3E)-1,3-pentadien-1-yl]-2H-pyran-2-yl]-2-hydroxy-1-methylbutyl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-, (3Z,5E,7R,8S,9S,11E,13E,15S,16R...
- CBNumber:
- CB31333205
- Molecular Formula:
- C43H68O12
- Molecular Weight:
- 776.99
- MDL Number:
- MFCD28898462
- MOL File:
- 108375-77-5.mol
- MSDS File:
- SDS
PC 766B price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20587 | PC-766B ≥95% | 108375-77-5 | 1mg | $275 | 2024-03-01 | Buy |
| Cayman Chemical | 20587 | PC-766B ≥95% | 108375-77-5 | 5mg | $1026 | 2024-03-01 | Buy |
| TRC | P216603 | PC-766B | 108375-77-5 | 1mg | $195 | 2021-12-16 | Buy |
| TRC | P216603 | PC-766B | 108375-77-5 | 2.5mg | $385 | 2021-12-16 | Buy |
| ApexBio Technology | C4269 | PC-766B | 108375-77-5 | 1mg | $312 | 2021-12-16 | Buy |
PC 766B Chemical Properties,Uses,Production
Description
PC-766B is a macrolide antibiotic produced by N. brasiliensis that is active against Gram-positive bacteria and some fungi, yet inactive against Gram-negative bacteria. It also demonstrates antitumor activity against mouse P388 leukemia and B16 melanoma cells in vitro (IC50s = 0.1 and 0.4 ng/ml, respectively) and in vivo, but weakly inhibits the Na+,K+-ATPase compared to structurally related antibiotics.
Uses
PC-766B is an antibiotic with activity against gram positive bacteria and some fungi and yeasts.
Uses
PC-766B is a 16-membered macrolide antibiotic produced by Nocardia brasiliensis, reported by researchers at Sumitomo in 1993. Structurally, PC-766B is a member of bafilomycin class, featuring a rare butadiene side-chain. PC-766B is active against Gram positive bacteria, and some fungi and yeasts, but is inactive against Gram negative bacteria. It shows activity against murine tumor cells in vitro and in vivo, and weak inhibitory activity against Na/K-ATPase in vitro.
References
[1] kumagai k, taya k, fukui a, et al. pc-766b, a new macrolide antibiotic produced by nocardia brasiliensis[j]. the journal of antibiotics, 1993, 46(6): 972-978.
PC 766B Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55954 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Meng Cheng Technology (Shanghai) Co., LTD | 400-820-6829 | sales@mitachieve.com | China | 8864 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| United States Biological | -- | sales@advtechind.com | United States | 6106 | 58 |