(+)-Aerothionin
- CAS No.
- 28714-26-3
- Chemical Name:
- (+)-Aerothionin
- Synonyms
- Aerothionin;(+)-Aerothionin;(+)-Aerothionin;N,N'-(1,4-Butanediyl)bis[(5S)-7,9-dibromo-8-methoxy-10α-hydroxy-1-oxa-2-azaspiro[4.5]deca-2,6,8-triene-3-carboxamide];N,N'-(1,4-Butanediyl)bis[(5S,10R)-7,9-dibromo-10-hydroxy-8-methoxy-1-oxa-2-azaspiro[4.5]deca-2,6,8-triene-3-carboxamide];1-Oxa-2-azaspiro[4.5]deca-2,6,8-triene-3-carboxamide, N,N'-1,4-butanediylbis[7,9-dibromo-10-hydroxy-8-methoxy-, (5S,5'S,10R,10'R)-
- CBNumber:
- CB32161939
- Molecular Formula:
- C24H26Br4N4O8
- Molecular Weight:
- 818.1
- MDL Number:
- MFCD14635399
- MOL File:
- 28714-26-3.mol
(+)-Aerothionin price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18459 | Aerothionin ≥97% | 28714-26-3 | 1mg | $153 | 2024-03-01 | Buy |
| TRC | A325703 | Aerothionin | 28714-26-3 | 5mg | $2050 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CN2-0453-M001 | Aerothionin ≥98%(HPLC) | 28714-26-3 | 1mg | $130 | 2021-12-16 | Buy |
| ApexBio Technology | C4405 | Aerothionin | 28714-26-3 | 1mg | $173 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0009897 | AEROTHIONIN 95.00% | 28714-26-3 | 5MG | $458.07 | 2021-12-16 | Buy |
(+)-Aerothionin Chemical Properties,Uses,Production
Occurrence
Aplysinajistularis yields this complex bromine-containing alkaloid which is an amorphous powder having no definite melting point. It is dextrorotatory with a specific rotation of [ulD +2100 (c 1.7, MeOH).
Uses
Aerothionin is a bromotyrosine derivative with antimycobacterial activity.
Biological Activity
aerothionin is derived from marine sponges with an antimycobacterial activity.antimycobacterial drugs are used in the treatment of diseases caused by mycobacterium genus, such as tuberculosis and leprosy.
in vitro
in a continuation of efforts to identify bioactive compounds from red sea verongid sponges, the organic extract of the sponge suberea species afforded seven compounds including aerothionin, together with two new dibrominated alkaloids and four known compounds. in-vitro cytotoxicity study showed that aerothionin and subereaphenol c had potent cytotoxic activity against hela cell line with ic50 values of 29 and 13.3 μm, respectively. [1].
in vivo
red sea suberea mollis sponge extract (smse), which contains aerothionin, was evaluated for its protective effect on carbon tetrachloride- (ccl4-) induced acute liver injury in rats. rats were orally administered three different concentrations of smse along with ccl4 for 14 days. smse could significantly reduce liver enzyme activities and hepatic mda formation. in addition, smse was able to restore no, sod, gsh, gpx, and cat. the histopathological results further confirmed these in-vivo findings [2].
IC 50
29 μm for hela cells proliferation
storage
+4°C
References
[1] shaala, l. a.,youssef, d.t.a.,badr, j.m., et al. bioactive secondary metabolites from the read sea marine verongid sponge suberea species. mar.drugs 13, 1621-1631 (2015).
[2] abbas at, el-shitany na, shaala la, ali ss, azhar ei, abdel-dayem ua, youssef dt. red sea suberea mollis sponge extract protects against ccl4-induced acute liver injury in rats via an antioxidant mechanism. evid based complement alternat med. 2014;2014:745606.
(+)-Aerothionin Preparation Products And Raw materials
Raw materials
Preparation Products
(+)-Aerothionin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |