ChemicalBook >> CAS DataBase List >>Pyranoridine phosphate
Pyranoridine phosphate
- CAS No.
- 76748-86-2
- Chemical Name:
- Pyranoridine phosphate
- Synonyms
- phosphate(1:4);pyranoridinephosphate;PYRANORIDINE TETRAPHOSPHATE;Pyranaridine tetraphosphate;76748-86-2 Pyranoridine phosphate;Pyranoridine phosphate ISO 9001：2015 REACH;4-((7-chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pheno;2-Methoxy-7-chloro-10[3′,5′-bis(pyrrolidinyl-1-methyl-)4′-hydroxyphenyl]aminobenzyl-(b)-1,5-naphthyridine tetraphosphate;4-[(7-Chloro-2-methoxy-1,5-dihydropyrido[3,2-b]quinolin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one phosphate (1:4);4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one,phosphoricaci
- CBNumber:
- CB3222539
- Molecular Formula:
- C29H35ClN5O6P
- Molecular Weight:
- 616.05
- MDL Number:
- MFCD05863545
- MOL File:
- 76748-86-2.mol
Last updated:2023-06-08 09:02:17
| Melting point | 233-236° (dec) |
|---|---|
| storage temp. | 2-8°C |
| solubility | acetic acid: soluble5mg/mL |
| form | solid |
| InChIKey | YKUQEKXHQFYULM-UHFFFAOYSA-N |
| FDA UNII | 2T289F9ACO |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H361 | |||||||||
| Precautionary statements | P280-P301+P312+P330 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 63-22-41 | |||||||||
| Safety Statements | 26-36/37-39 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | SK4920000 | |||||||||
| Toxicity | LD50 in mice (mg/kg): 251 ±33 i.m.; 1368 ±239 orally (Shao) | |||||||||
| NFPA 704 |
|
Pyranoridine phosphate price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P0049 | Pyronaridine tetraphosphate | 76748-86-2 | 250MG | $265 | 2023-06-20 | Buy |
| Cayman Chemical | 16139 | Pyronaridine (phosphate) ≥98% | 76748-86-2 | 50mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 16139 | Pyronaridine (phosphate) ≥98% | 76748-86-2 | 100mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 16139 | Pyronaridine (phosphate) ≥98% | 76748-86-2 | 250mg | $201 | 2024-03-01 | Buy |
| TRC | P997640 | Pyronaridine tetraphosphate | 76748-86-2 | 50mg | $325 | 2021-12-16 | Buy |
Pyranoridine phosphate Chemical Properties,Uses,Production
Uses
Pyronaridine Phosphate is an antimalarial drug.
Biological Activity
pyronaridine (pnd), a synthetic quinolone derivative frequently prescribed for the treatment of malaria, is a selective and potent multidrug resistance (mdr) modulator of pgp-mediated mdr that inhibits the proliferation of a variety of tumor cells, including myeloid leukemia (k562 and k562/a02), epidermoid carcinoma (kb and kbv200), breast carcinoma (mcf-7 and mcf-7/adr), ovarian carcinoma (skov3, es-2 and pa-1), gastric carcinoma (bgc-823), colon carcinoma (lovo), hepatocellular carcinoma (smmz-7721 and qgy-7703), with the half maximal inhibition concentration ic50 values of 8.3 μm, 5.6 μm, 20.8 μm, 14.5 μm, 9.5 μm, 11 μm, 9.7 μm, 12.9 μm, 15.7 μm, 14.9 μm, 21.4 μm, 10.9 μm and 17.1 μm respectively [1].
References
[1] qi j, wang s, liu g, peng h, wang j, zhu z, yang c. pyronaridine, a novel modulator of p-glycoprotein-mediated multidrug resistance in tumor cells in vitro and in vivo. biochem biophys res commun. 2004 jul 9;319(4):1124-31.
Pyranoridine phosphate Preparation Products And Raw materials
Raw materials
Preparation Products
Pyranoridine phosphate Suppliers
Global( 55)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28200 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | peter68@ptchemgroup.com | China | 35453 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
View Lastest Price from Pyranoridine phosphate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-10-22 | Pyranoridine phosphate
76748-86-2
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited |
-
- Pyranoridine phosphate
76748-86-2
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
76748-86-2(Pyranoridine phosphate)Related Search:
PYRANORIDINE TETRAPHOSPHATE
4-((7-chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pheno
phosphate(1:4)
pyranoridinephosphate
Pyranaridine tetraphosphate
4-[(7-Chloro-2-methoxy-1,5-dihydropyrido[3,2-b]quinolin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one phosphate (1:4)
2-Methoxy-7-chloro-10[3′,5′-bis(pyrrolidinyl-1-methyl-)4′-hydroxyphenyl]aminobenzyl-(b)-1,5-naphthyridine tetraphosphate
4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one,phosphoricaci
Pyranoridine phosphate ISO 9001：2015 REACH
4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one,phosphoric acid
76748-86-2 Pyranoridine phosphate
76748-86-2
C29H32ClN5O24H3PO4
C29H32ClN5O24H3O4P
Inhibitor