N-(2-Aminophenyl)-N'-phenylheptanediamide
- CAS No.
- 537034-15-4
- Chemical Name:
- N-(2-Aminophenyl)-N'-phenylheptanediamide
- Synonyms
- NKL 22;MDK-4154;HDACi-4b;NKL22, >98%;NKL 22, >98%;HDAC inhibitor IV;Histone Deacetylase Inhibitor IV;N-(2-Aminophenyl)-N'-phenylheptanediamide;N1-(2-AMinophenyl)-N7-phenylheptanediaMide;Heptanediamide, N1-(2-aminophenyl)-N7-phenyl-
- CBNumber:
- CB32486755
- Molecular Formula:
- C19H23N3O2
- Molecular Weight:
- 325.4
- MDL Number:
- MFCD16293760
- MOL File:
- 537034-15-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| NFPA 704 |
|
N-(2-Aminophenyl)-N'-phenylheptanediamide price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 382170 | Histone Deacetylase Inhibitor IV - CAS 537034-15-4 - Calbiochem | 537034-15-4 | 10mg | $335 | 2023-01-07 | Buy |
| Cayman Chemical | 22942 | PAOA ≥95% | 537034-15-4 | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 22942 | PAOA ≥95% | 537034-15-4 | 10mg | $176 | 2024-03-01 | Buy |
| Cayman Chemical | 22942 | PAOA ≥95% | 537034-15-4 | 25mg | $412 | 2024-03-01 | Buy |
| TRC | A625980 | N-(2-Aminophenyl)-N’-phenylheptanediamide | 537034-15-4 | 5mg | $120 | 2021-12-16 | Buy |
N-(2-Aminophenyl)-N'-phenylheptanediamide Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
Histone deacetylase inhibitor IV. A cell-permeable pimeloylanilide compound that acts as a FXN-(frataxin gene) specific HDAC inhibitor. Reverses the silencing of FXN transcription in FRDA (Friedrich’s ataxia) cells due to hypoacetylation of histones H3 and H4.
General Description
A cell-permeable pimeloylanilide compound that acts as a FXN- (frataxin gene) specific HDAC (histone deacetylase) inhibitor. Reverses the silencing of FXN transcription in FRDA (Friedreich′s ataxia) cells (~3-fold increase of FXN mRNA at 5 μM in primary FRDA lymphocytes and ~3-fold frataxin expression in FRDA cell line at 2.5 μM) due to hypoacetylation of histones H3 and H4 by increasing acetylation at H3K14, H4K5 and H4K12, without significant changes in acetylation at H3K9, H4K8 and H4K16. In comparison, Trichostatin-A (Cat. No. 647925 and 647926) and SAHA, two other commonly used HDAC inhibitors, exhibit no effect on FXN transcription.
Biochem/physiol Actions
Cell permeable: yes
N-(2-Aminophenyl)-N'-phenylheptanediamide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |