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4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride structure

CAS No.: 950912-80-8

Chemical Name:: 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride

Synonyms: CS-318;PF 67046;PF 670462;PF-670462 HCL;PF-670462 2HCl;PF 670462, >=98%;PF670462/ PF-670462;PF670462 dihydrochloride;PF-670462 (hydrochloride);Casein Kinase I Inhibitor II, PF-670462

CBNumber:: CB32518984

Molecular Formula:: C19H20FN5.2HCl

Molecular Weight:: 410

MDL Number:: MFCD12828759

MOL File:: 950912-80-8.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

Request For Quotation

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride Properties

Melting point	>178°C (dec.)
storage temp.	2-8°C
solubility	H2O: soluble2mg/mL, clear (warmed)
form	powder
color	white to beige
InChIKey	PSNKGVAXBSAHCH-UHFFFAOYSA-N
FDA UNII	D68ANS5I8B

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
WGK Germany	3

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SML0795	PF-670462 ≥98% (HPLC)	950912-80-8	5mg	$132	2024-03-01	Buy
Cayman Chemical	14588	PF-670462 (hydrochloride) ≥99%	950912-80-8	10mg	$166	2024-03-01	Buy
Cayman Chemical	14588	PF-670462 (hydrochloride) ≥99%	950912-80-8	50mg	$576	2024-03-01	Buy
Sigma-Aldrich	SML0795	PF-670462 ≥98% (HPLC)	950912-80-8	25mg	$537	2024-03-01	Buy
Tocris	3316	PF670462 ≥99%(HPLC)	950912-80-8	50	$980	2021-12-16	Buy

Product number	Packaging	Price	Buy
SML0795	5mg	$132	Buy
14588	10mg	$166	Buy
14588	50mg	$576	Buy
SML0795	25mg	$537	Buy
3316	50	$980	Buy

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride Chemical Properties,Uses,Production

Description

The casein kinase 1 (CK1) family of kinases regulate diverse processes, particularly related to circadian rhythms and sensitivity to amphetamines. PF-670462 is a potent inhibitor of the CK1 isoforms CK1ε and CK1δ (IC₅₀ = 7.7 and 14 nM, respectively). It less effectively inhibits a wide variety of related or common kinases. Through its effects on CK1, PF-670462 disrupts circadian rhythms in cells and animals. It also blocks the locomotor response to amphetamines in mice.

Uses

PF 670462 is a potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor. PF 670462 has been shown to inhibit PER protein nuclear translocation causing phase shifts in circadian rhythms. PF 670462 attenuates methamphetamine-stimulated locomotion in vivo.

Definition

ChEBI: A hydrochloride salt resulting from the formal reaction of 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine with 2 mol eq. of hydrogen chloride. It is a selectiv inhibitor of the delta- and epsilon-isoforms of casein kinase 1 (CK1delta and CK1epsilon).

Biochem/physiol Actions

PF-670462 is also termed as 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine dihydrochloride). It participates in ceramide transfer between Golgi and ER (endoplasmic reticulum) compartments. PF-670462 affects actin filament consolidation. It also hinders the stability at the front edge of cells treated with N-formyl Met-Leu-Phe.

storage

room temperature (desiccate)

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride Suppliers

Global( 98)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9341	55
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58

Supplier	Advantage
Hangzhou FandaChem Co.,Ltd.	55
BOC Sciences	58
career henan chemical co	58
Alfa Chemistry	58
InvivoChem	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58

View Lastest Price from 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-03-12	4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride 950912-80-8	US $1.00 / KG	100KG	99.0%	1000kg	Career Henan Chemical Co

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride
950912-80-8
US $1.00 / KG
99.0%
Career Henan Chemical Co

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride Spectrum

4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride(950912-80-8)¹HNMR

950912-80-8(4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride)Related Search:

2-FLUOROPHENYL CYCLOPENTYL KETONE TRIS(PENTAFLUOROPHENYL)BORANE

PF670462/ PF-670462 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine hydrochloride 2-PyriMidinaMine, 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-iMidazol-5-yl]-, hydrochloride (1:2) PF 67046 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine hydrochloride PF670462 4-[3-Cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-yl]-pyrimidin-2-ylamine dihydrochloride PF 670462, >=98% PF 670462 PF-670462 2HCl PF-670462 (hydrochloride) Casein Kinase I Inhibitor II, PF-670462 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinaminedihydrochloride 4-[3-cyclohexyl-5-(4-fluorophenyl)imidazol-4-yl]pyrimidin-2-amine:dihydrochloride Casein Kinase I Inhibitor II, PF-670462 - CAS 950912-80-8 - Calbiochem 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]pyrimidin-2-amine dihydrochloride CS-318 PF670462 dihydrochloride PF-670462 HCL 950912-80-8 C19H20FN52HCl C19H22Cl2FN5 C19H20FN52ClH Inhibitors Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Protein Kinase Inhibitors and Activators