BMS 195614
- CAS No.
- 253310-42-8
- Chemical Name:
- BMS 195614
- Synonyms
- BMS 195614;4-[[[5,6-Dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]benzoic acid;BMS-195614 4-[[[5,6-Dihydro-5,5-dimethyl-8-(3-quinolinyl)-2-naphthalenyl]carbonyl]amino]benzoic acid
- CBNumber:
- CB32546787
- Molecular Formula:
- C29H24N2O3
- Molecular Weight:
- 448.51246
- MDL Number:
- MOL File:
- 253310-42-8.mol
- MSDS File:
- SDS
BMS 195614 price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 3660 | BMS195614 ≥98%(HPLC) | 253310-42-8 | 10 | $266 | 2021-12-16 | Buy |
| Tocris | 3660 | BMS195614 ≥98%(HPLC) | 253310-42-8 | 50 | $1088 | 2021-12-16 | Buy |
| Usbiological | 254786 | BMS 195614 | 253310-42-8 | 10mg | $516 | 2021-12-16 | Buy |
| TRC | B695580 | BMS195614 | 253310-42-8 | 2.5mg | $250 | 2021-12-16 | Buy |
| ApexBio Technology | B7459 | BMS195614 | 253310-42-8 | 10mg | $261 | 2021-12-16 | Buy |
BMS 195614 Chemical Properties,Uses,Production
Uses
BMS 195614, is a selective neutral RARα inhibitor and exhibits no significant effect on NCoR binding. It decreases agonist-induced coactivator recruitment and SMRT binding to RAR. RARs, or Retinoic Acid Receptors, are nuclear hormone receptors that form heterodimers with RXRs (Retinoid X Receptors).
Definition
ChEBI: BMS 195614 is a carboxamide resulting from the formal condensation of the carboxy group of 5,5-dimethyl-8-(quinolin-3-yl)-5,6-dihydronaphthalene-2-carboxylic acid with the amino group of p-aminobenzoic acid. It is a neutral retinoic acid receptor (RAR) alpha-selective antagonist (Ki = 2.5 nM). It displays no significant effect on nuclear receptor corepressor (NCoR) binding; moderately decreases SMRT binding to RAR. It antagonizes agonist-induced coactivator (CoA) recruitment. It has a role as a retinoic acid receptor alpha antagonist. It is a member of quinolines, a member of benzoic acids and a secondary carboxamide.
BMS 195614 Preparation Products And Raw materials
Raw materials
Preparation Products
BMS 195614 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 3614 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
| Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | sales@tybiochem.com | China | 5141 | 58 |