PF 4800567 hydrochloride
- CAS No.
- 1188296-52-7
- Chemical Name:
- PF 4800567 hydrochloride
- Synonyms
- PF 4800567;PF 4800567;PF-4800567;PF 4800567 hydrochloride;Casein Kinase,PF4800567,inhibit,PF-4800567,PF 4800567,Inhibitor;3-[(3-chlorophenoxy)methyl]-1-(oxan-4-yl)pyrazolo[3,4-d]pyrimidin-4-amine;3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-;3-[(3-Chlorophenoxy)Methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyriMidin-4-aMine Hydrochloride
- CBNumber:
- CB32561076
- Molecular Formula:
- C17H18ClN5O2
- Molecular Weight:
- 359.81
- MDL Number:
- MFCD22123245
- MOL File:
- 1188296-52-7.mol
| Boiling point | 592.9±50.0 °C(Predicted) |
|---|---|
| Density | 1.52±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml |
| form | A crystalline solid |
| pka | 4.01±0.30(Predicted) |
| FDA UNII | GEE72DRC63 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
PF 4800567 hydrochloride price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19171 | PF-4800567 ≥98% | 1188296-52-7 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 19171 | PF-4800567 ≥98% | 1188296-52-7 | 5mg | $142 | 2024-03-01 | Buy |
| Cayman Chemical | 19171 | PF-4800567 ≥98% | 1188296-52-7 | 10mg | $231 | 2024-03-01 | Buy |
| Cayman Chemical | 19171 | PF-4800567 ≥98% | 1188296-52-7 | 25mg | $530 | 2024-03-01 | Buy |
| Tocris | 4281 | PF4800567hydrochloride ≥99%(HPLC) | 1188296-52-7 | 10 | $227 | 2021-12-16 | Buy |
PF 4800567 hydrochloride Chemical Properties,Uses,Production
Description
PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ. It blocks CK1ε-mediated PER3 nuclear localization and PER2 degradation, both of which are proteins important for maintaining circadian rhythms in cells. PF-4800567 has been used in the study of the CK1 enzymes in the regulation of circadian rhythm and is also reported to have neuroprotective effects.
Uses
PF 4800567 is a selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock.
Definition
ChEBI: PF-4800567 is a pyrazolopyrimidine that is 1H-pyrazolo[3,4-d]pyrimidin-4-amine which is substituted at positions 1 and 3 by tetrahydro-2H-pyran-4-yl and (m-chlorophenoxy)methyl groups, respectively. It is a selective inhibitor of the epsilon isoform of casein kinase 1 (CK1epsilon). It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It is a pyrazolopyrimidine, a member of monochlorobenzenes, an aromatic ether and a member of oxanes.
PF 4800567 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Guangzhou Zhiya Chemdrugs Co.,Ltd | 18122150900 | sculk28@163.com | China | 646 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |