Islatravir | 865363-93-5

Islatravir Properties

Melting point	220.0-221.4 °C (decomp)
Boiling point	669.2±65.0 °C(Predicted)
Density	1.72±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:100.0(Max Conc. mg/mL);341.0(Max Conc. mM) Water:3.57(Max Conc. mg/mL);12.17(Max Conc. mM)
form	A solid
pka	13.11±0.60(Predicted)
InChI	InChI=1S/C12H12FN5O3/c1-2-12(4-19)6(20)3-7(21-12)18-5-15-8-9(14)16-11(13)17-10(8)18/h1,5-7,19-20H,3-4H2,(H2,14,16,17)/t6-,7+,12+/m0/s1
InChIKey	IKKXOSBHLYMWAE-QRPMWFLTSA-N
SMILES	OC[C@@]1(C#C)O[C@@H](N2C3C(=C(N=C(F)N=3)N)N=C2)C[C@@H]1O
FDA UNII	QPQ082R25D

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P280-P301+P312-P302+P352-P305+P351+P338

NFPA 704

	0
2		0

Islatravir price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0023675	Islatravir 99.94%	865363-93-5	5mg	$500	2021-12-16	Buy
Axon Medchem	Axon3191	Islatravir-EFdA\|MK-8591 99%	865363-93-5	2x5mg	$792	2021-12-16	Buy
ChemScene	CS-0023675	Islatravir 99.94%	865363-93-5	10mg	$850	2021-12-16	Buy
ChemScene	CS-0023675	Islatravir 99.94%	865363-93-5	25mg	$1800	2021-12-16	Buy
ChemScene	CS-0023675	Islatravir 99.94%	865363-93-5	50mg	$3000	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0023675	5mg	$500	Buy
Axon3191	2x5mg	$792	Buy
CS-0023675	10mg	$850	Buy
CS-0023675	25mg	$1800	Buy
CS-0023675	50mg	$3000	Buy

Islatravir Chemical Properties,Uses,Production

Description

Islatravir belongs to a group of HIV drugs called nucleoside reverse transcriptase translocation inhibitors (NRTTIs). NRTTIs use several different methods to block an HIV enzyme called reverse transcriptase. By blocking reverse transcriptase, NRTTIs prevent HIV from multiplying and can reduce the amount of HIV in the body. This compound may be effective against certain HIV strains that are resistant to other HIV drugs.

Uses

MK-?8591 is a carbocyclic nucleoside reverse transcriptase translocation inhibitor and is used as an antiviral with potential use towards the treatment of HIV.

Uses

4'-ethynyl-2-fluoro-2'-deoxyadenosine (Islatravir) is a heterocyclic organic compound and can be used as pharmaceutical intermediates.

Mechanism of action

Islatravir belongs to a group of HIV drugs called nucleoside reverse transcriptase translocation inhibitors (NRTTIs). NRTTIs use several different methods to block an HIV enzyme called reverse transcriptase. By blocking reverse transcriptase, NRTTIs prevent HIV from multiplying and can reduce the amount of HIV in the body. This compound may be effective against certain HIV strains that are resistant to other HIV drugs[1].

Pharmacokinetics

Islatravir is converted intracellularly by endogenous kinases to its active triphosphate (TP) form, islatravir-TP, which has a long intracellular half-life, allowing the potential for various dosing options and regimens. In participants without HIV, single oral doses of islatravir were rapidly absorbed, with peak plasma concentrations attained at ~ 0.5 h, with islatravir demonstrating a half-life of ~ 49–61 h. Peak intracellular islatravir-TP concentrations were attained 6–24 h after islatravir administration, with a half-life of 118–171 h; similar pharmacokinetics have been observed in people living with HIV-1. When administered once daily (QD), oral doses of islatravir resulted in steady-state plasma concentrations at approximately Day 14. At the same time, intracellular islatravir-TP reached a steady state by Day 28 and remained above the concentration threshold associated with antiviral efficacy (0.05 pmol/106 cells) for ~ 30 days following cessation of dosing. In addition, doses as low as 0.25 mg QD produced intracellular islatravir-TP concentrations exceeding the therapeutic concentration threshold on Day 1[1].

References

[1] Randolph P Matthews. “A Phase 1 Study to Evaluate the Drug Interaction Between Islatravir (MK-8591) and Doravirine in Adults Without HIV.” Clinical Drug Investigation (2021): 629–638.

Islatravir Preparation Products And Raw materials

Raw materials

Preparation Products

Islatravir Suppliers

Global( 74)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
NewCan Biotech Limited	+86-0571-86912261 +8613735419629	sales@newcanbio.com	China	9978	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10247	58
Beijing Ribio Biotech Co.,Ltd	010-62664360 +8613328773880	wucy@ribio.com.cn	China	117	58
Yunbio Tech Co.,Ltd.	+86-010-60605551 +86-18046518538	yunbiochem@126.com	China	321	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5909	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58

Supplier	Advantage
Amadis Chemical Company Limited	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
NewCan Biotech Limited	58
Henan Tianfu Chemical Co.,Ltd.	55
Shenzhen Nexconn Pharmatechs Ltd	58
Beijing Ribio Biotech Co.,Ltd	58
Yunbio Tech Co.,Ltd.	58
Shandong chuangyingchemical Co., Ltd.	58
BOC Sciences	58
TargetMol Chemicals Inc.	58

View Lastest Price from Islatravir manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-05-22	Islatravir 865363-93-5	US $0.00-0.00 / mg	100mg	98%	10g	NewCan Biotech Limited
2024-02-06	4'-ethynyl-2-fluoro-2'-deoxyadenosine EFDA E2FDA 865363-93-5	US $4000.00 / g	1g	95%	10KGS	Yunbio Tech Co.,Ltd.
2021-09-29	4'-ethynyl-2-fluoro-2'-deoxyadenosine/EFDA 865363-93-5	US $0.00 / g	1g	95%min	10G	WUHAN FORTUNA CHEMICAL CO., LTD

Islatravir
865363-93-5
US $0.00-0.00 / mg
98%
NewCan Biotech Limited

4'-ethynyl-2-fluoro-2'-deoxyadenosine EFDA E2FDA
865363-93-5
US $4000.00 / g
95%
Yunbio Tech Co.,Ltd.

4'-ethynyl-2-fluoro-2'-deoxyadenosine/EFDA
865363-93-5
US $0.00 / g
95%min
WUHAN FORTUNA CHEMICAL CO., LTD

865363-93-5(Islatravir)Related Search:

(R, S)-Adenosyl-L-Methionine ADENOSINE 5'-TRIPHOSPHATE DISODIUM SAL& Adenosine-5'-diphosphate disodium salt ADENOSINE5'-MONOPHOSPHATESODIUMSALT 8-AMino[1”-(N”-dansyl)-4”-aMinobutyl]-5'-(1-aziridinyl)-5'-deoxy Adenosine

Ademetionine 1,4-butanedisulfonate (S, S)-Adenosyl-L-Methionine Ademetionine disulfate tosylate Adenosine 5'-monophosphate Decarboxy-S-adenosylmethionine

5'-DEOXY-5'-METHYLTHIOADENOSINE 2,3,5-TRI-O-ACETYL-6-CHLOROPURINE-9-?-D-RIBOFURANOSIDE S-Adenosyl-L-methionine 2-methylthio-N-6-isopentenyladenosine Adenosine-13C5

2'-O-MB-CAMP SODIUM SALT Adenosine Related Compound 1 Adenosyl Methionine Impurity 2

1of4

4'-ethynyl-2-fluoro-2'-deoxyadenosine EFdA 2'-deoxy-4'-C-ethynyl-2-fluoro-Adenosine E2FDA 2'-Deoxy-4'-ethynyl-2-fluoroadenosine 4'-ethynyl-2-fluoro-2'-deoxyadenosine EFDA E2FDA Islatravir Adenosine Related Compound Adenosine Related Compound 6 (MK-8591) (2R,3S,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-2-ethynyl-2-(hydroxymethyl)tetrahydrofuran-3-ol Adenosine, 2'-deoxy-4'-C-ethynyl-2-fluoro- Adenosine Impurity 22 4'-ethynyl-2-fluoro-2'-deoxyadenosine/EFDA Islatravir(MK-8591) (2R,3S,5R)-5-(6-amino-2-fluoro-4H-purin-9(5H)-yl)-2-ethynyl-2-(hydroxymethyl)-tetrahydrofuran-3-ol (2R,3S,5R)-5-(6-amino-2-fluoropurin-9-yl)-2-ethynyl-2-(hydroxymethyl)oxolan-3-ol Human immunodeficiency virus,Inhibitor,Islatravir,MK 8591,inhibit,MK8591,Reverse Transcriptase,HIV MK-8591 (Islatravir) 2-DEOXY-4-C-ETHYNYL-2-FLUORO- 4'-ethynyl-2-fluoro-2'-deoxyadenosine 865363-93-5 C12H12FN5O3