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Cariprazine-d6

Cariprazine-d6 Structure
Cariprazine-d6 structure
CAS No.
1308278-67-2
Chemical Name:
Cariprazine-d6
Synonyms
Cariprazine-d6;N'-[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-N,N-di(methyl-d3)-urea
CBNumber:
CB32673724
Molecular Formula:
C21H32Cl2N4O
Molecular Weight:
427.41
MDL Number:
MOL File:
1308278-67-2.mol
Last updated:2023-06-08 09:03:09
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Cariprazine-d6 Properties

storage temp. Store at -20°C
solubility DMSO: soluble
form A solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P501
NFPA 704
0
3 0

Cariprazine-d6 price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 29449 Cariprazine-d6 1308278-67-2 1mg $384 2024-03-01 Buy
Product number Packaging Price Buy
29449 1mg $384 Buy

Cariprazine-d6 Chemical Properties,Uses,Production

Description

Cariprazine-d6 is intended for use as an internal standard for the quantification of cariprazine by GC- or LC-MS. Cariprazine is an atypical antipsychotic.1 It binds to dopamine D2L, D2S, and D3 receptors, the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT2A, and 5-HT2B, and histamine H1 and sigma-1 (σ1) receptors (Kis = 0.085-23.44 nM).2 Cariprazine is an antagonist of dopamine D2 and D3 receptors (Kbs = 0.759 and 0.316 nM, respectively, in dopamine-induced [35S]GTPγS binding assays). It is also a partial agonist at these receptors, stimulating inositol phosphate production in murine A9 cells expressing human D2L receptors (EC50 = 3.16 nM) and inhibiting forskolin-induced cAMP accumulation in CHO cells expressing human D3 receptors (EC50 = 2.63 nM). Cariprazine inhibits amphetamine-induced hyperactivity and the conditioned avoidance response in rats (ED50s = 0.12 and 0.84 mg/kg, respectively).3 It also inhibits scopolamine-induced learning deficits in a water labyrinth learning test in rats when administered at doses ranging from 0.02 to 0.08 mg/kg. Formulations containing cariprazine have been used in the treatment of schizophrenia, as well as manic, depressive, or mixed episodes associated with bipolar I disorder.

References

1. Mészáros, G.P., Agai-Csongor, E., and Kapás, M. Sensitive LC-MS/MS methods for the quantification of RGH-188 and its active metabolites, desmethyl- and didesmethyl-RGH-188 in human plasma and urine J. Pharm. Biomed. Anal. 48(2),388-397(2008).
2. Kiss, B., Horváth, A., Némethy, Z., et al. Cariprazine (RGH-188), a dopamine D3 receptor-preferring, D3/D2 dopamine receptor antagonist-partial agonist antipsychotic candidate: In vitro and neurochemical profile J. Pharmacol. Exp. Ther. 333(1),328-340(2010).
3. Gyertyán, I., Kiss, B., Sághy, K., et al. Cariprazine (RGH-188), a potent D3/D2 dopamine receptor partial agonist, binds to dopamine D3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodents Neurochem. Int. 59(6),925-935(2011).

Cariprazine-d6 Preparation Products And Raw materials

Raw materials

Preparation Products

Cariprazine-d6 Suppliers

Global( 23)Suppliers
Supplier Tel Email Country ProdList Advantage
SIMSON PHARMA LIMITED 		+91-8291074273 k.das@simsonpharma.com India 228 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Artis Biotech Co. Ltd. 19138486554 18582380095 sales@artisbio.com China 2804 58
Chengdu Novel Biomedical Co., Ltd. 028-85255396 18302801538 cdnovell@163.com China 2251 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
Jinan blalong chemical co. LTD 2710913286@.com 1513643261@qq.com China 14253 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Wuxi Minglu Medicine technology Co.,Ltd. 0510-88726693 3204601684@qq.com China 1896 58
Guangzhou Juntang Technology Co., Ltd 020-36607679 13502246435 sales@dmstandards.com China 10951 58
cjbscvictory 13348960310 13348960310 3003867561@qq.com China 10011 58
Supplier Advantage
SIMSON PHARMA LIMITED 		58
Aladdin Scientific 		58
Artis Biotech Co. Ltd. 58
Chengdu Novel Biomedical Co., Ltd. 58
Shanghai Hongye Biotechnology Co. Ltd 58
Jinan blalong chemical co. LTD 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Wuxi Minglu Medicine technology Co.,Ltd. 58
Guangzhou Juntang Technology Co., Ltd 58
cjbscvictory 58

View Lastest Price from Cariprazine-d6 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cariprazine-D6 pictures 2023-05-27 Cariprazine-D6
1308278-67-2
 US $0.00-0.00 / mg 1mg 96% 50 mg Simson Pharma limited

1308278-67-2(Cariprazine-d6)Related Search:

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3,3-dimethyl-1-[(1r,4r)-4-(2-hydroxyethyl)cyclohexyl]urea Cyclohexaneethanol, 4-amino-, hydrochloride (1:1), trans- Cariprazine Impurity 3 Cariprazine Cariprazine Impurity 4

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Cariprazine-d6 N'-[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-N,N-di(methyl-d3)-urea 1308278-67-2